Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products
Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we ai...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/17/5/249 |
| _version_ | 1818007543576788992 |
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| author | Ramesh Subramani Detmer Sipkema |
| author_facet | Ramesh Subramani Detmer Sipkema |
| author_sort | Ramesh Subramani |
| collection | DOAJ |
| description | Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera <i>Nocardiopsis</i>, <i>Micromonospora</i>, <i>Salinispora</i> and <i>Pseudonocardia</i>. Members of the genus <i>Micromonospora</i> were revealed to be the richest source of chemically diverse and unique bioactive natural products. |
| first_indexed | 2024-04-14T05:17:01Z |
| format | Article |
| id | doaj.art-ea3fdbd3817343f9a80e39bce48e0772 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T05:17:01Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ea3fdbd3817343f9a80e39bce48e07722022-12-22T02:10:20ZengMDPI AGMarine Drugs1660-33972019-04-0117524910.3390/md17050249md17050249Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural ProductsRamesh Subramani0Detmer Sipkema1School of Biological and Chemical Sciences, Faculty of Science, Technology & Environment, The University of the South Pacific, Laucala Campus, Private Mail Bag, Suva, Republic of FijiLaboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The NetherlandsRare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera <i>Nocardiopsis</i>, <i>Micromonospora</i>, <i>Salinispora</i> and <i>Pseudonocardia</i>. Members of the genus <i>Micromonospora</i> were revealed to be the richest source of chemically diverse and unique bioactive natural products.https://www.mdpi.com/1660-3397/17/5/249rare actinomycetesmarine actinobacteriacultivationnatural productsbioactive compounds |
| spellingShingle | Ramesh Subramani Detmer Sipkema Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products Marine Drugs rare actinomycetes marine actinobacteria cultivation natural products bioactive compounds |
| title | Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
| title_full | Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
| title_fullStr | Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
| title_full_unstemmed | Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
| title_short | Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products |
| title_sort | marine rare actinomycetes a promising source of structurally diverse and unique novel natural products |
| topic | rare actinomycetes marine actinobacteria cultivation natural products bioactive compounds |
| url | https://www.mdpi.com/1660-3397/17/5/249 |
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