Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients.
<h4>Importance</h4>The rapid pandemic expansion of the disease caused by the new SARS-CoV-2 virus has compromised health systems worldwide. Knowledge of prognostic factors in affected patients can help optimize care.<h4>Objective</h4>The objective of this study was to analyze...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0239571 |
| _version_ | 1819035187484295168 |
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| author | Alejandro Rodríguez-Molinero César Gálvez-Barrón Antonio Miñarro Oscar Macho Gabriela F López Maria Teresa Robles María Dolores Dapena Sergi Martínez Núria Milà Ràfols Ernesto E Monaco Antonio Hidalgo García COVID-19 Research Group of CSAPG |
| author_facet | Alejandro Rodríguez-Molinero César Gálvez-Barrón Antonio Miñarro Oscar Macho Gabriela F López Maria Teresa Robles María Dolores Dapena Sergi Martínez Núria Milà Ràfols Ernesto E Monaco Antonio Hidalgo García COVID-19 Research Group of CSAPG |
| author_sort | Alejandro Rodríguez-Molinero |
| collection | DOAJ |
| description | <h4>Importance</h4>The rapid pandemic expansion of the disease caused by the new SARS-CoV-2 virus has compromised health systems worldwide. Knowledge of prognostic factors in affected patients can help optimize care.<h4>Objective</h4>The objective of this study was to analyze the relationship between the prognosis of COVID-19 and the form of presentation of the disease, the previous pathologies of patients and their chronic treatments.<h4>Design, participants and locations</h4>This was an observational study on a cohort of 418 patients admitted to three regional hospitals in Catalonia (Spain). As primary outcomes, severe disease (need for oxygen therapy via nonrebreather mask or mechanical ventilation) and death were studied. Multivariate binary logistic regression models were performed to study the association between the different factors and the results.<h4>Results</h4>Advanced age, male sex and obesity were independent markers of poor prognosis. The most frequent presenting symptom was fever, while dyspnea was associated with severe disease and the presence of cough with greater survival. Low oxygen saturation in the emergency room, elevated CRP in the emergency room and initial radiological involvement were all related to worse prognosis. The presence of eosinophilia (% of eosinophils) was an independent marker of less severe disease.<h4>Conclusions</h4>This study identified the most robust markers of poor prognosis for COVID-19. These results can help to correctly stratify patients at the beginning of hospitalization based on the risk of developing severe disease. |
| first_indexed | 2024-12-21T07:45:38Z |
| format | Article |
| id | doaj.art-ea4062f1dbbb4d4da7afb4cb40561750 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T07:45:38Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ea4062f1dbbb4d4da7afb4cb405617502022-12-21T19:11:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e023957110.1371/journal.pone.0239571Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients.Alejandro Rodríguez-MolineroCésar Gálvez-BarrónAntonio MiñarroOscar MachoGabriela F LópezMaria Teresa RoblesMaría Dolores DapenaSergi MartínezNúria Milà RàfolsErnesto E MonacoAntonio Hidalgo GarcíaCOVID-19 Research Group of CSAPG<h4>Importance</h4>The rapid pandemic expansion of the disease caused by the new SARS-CoV-2 virus has compromised health systems worldwide. Knowledge of prognostic factors in affected patients can help optimize care.<h4>Objective</h4>The objective of this study was to analyze the relationship between the prognosis of COVID-19 and the form of presentation of the disease, the previous pathologies of patients and their chronic treatments.<h4>Design, participants and locations</h4>This was an observational study on a cohort of 418 patients admitted to three regional hospitals in Catalonia (Spain). As primary outcomes, severe disease (need for oxygen therapy via nonrebreather mask or mechanical ventilation) and death were studied. Multivariate binary logistic regression models were performed to study the association between the different factors and the results.<h4>Results</h4>Advanced age, male sex and obesity were independent markers of poor prognosis. The most frequent presenting symptom was fever, while dyspnea was associated with severe disease and the presence of cough with greater survival. Low oxygen saturation in the emergency room, elevated CRP in the emergency room and initial radiological involvement were all related to worse prognosis. The presence of eosinophilia (% of eosinophils) was an independent marker of less severe disease.<h4>Conclusions</h4>This study identified the most robust markers of poor prognosis for COVID-19. These results can help to correctly stratify patients at the beginning of hospitalization based on the risk of developing severe disease.https://doi.org/10.1371/journal.pone.0239571 |
| spellingShingle | Alejandro Rodríguez-Molinero César Gálvez-Barrón Antonio Miñarro Oscar Macho Gabriela F López Maria Teresa Robles María Dolores Dapena Sergi Martínez Núria Milà Ràfols Ernesto E Monaco Antonio Hidalgo García COVID-19 Research Group of CSAPG Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. PLoS ONE |
| title | Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. |
| title_full | Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. |
| title_fullStr | Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. |
| title_full_unstemmed | Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. |
| title_short | Association between COVID-19 prognosis and disease presentation, comorbidities and chronic treatment of hospitalized patients. |
| title_sort | association between covid 19 prognosis and disease presentation comorbidities and chronic treatment of hospitalized patients |
| url | https://doi.org/10.1371/journal.pone.0239571 |
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