Applications of Transistor-Based Biochemical Sensors
Transistor-based biochemical sensors feature easy integration with electronic circuits and non-invasive real-time detection. They have been widely used in intelligent wearable devices, electronic skins, and biological analyses and have shown broad application prospects in intelligent medical detecti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/4/469 |
| _version_ | 1797606249186983936 |
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| author | Qiya Gao Jie Fu Shuang Li Dong Ming |
| author_facet | Qiya Gao Jie Fu Shuang Li Dong Ming |
| author_sort | Qiya Gao |
| collection | DOAJ |
| description | Transistor-based biochemical sensors feature easy integration with electronic circuits and non-invasive real-time detection. They have been widely used in intelligent wearable devices, electronic skins, and biological analyses and have shown broad application prospects in intelligent medical detection. Field-effect transistor (FET) sensors have high sensitivity, reasonable specificity, rapid response, and portability and provide unique signal amplification during biochemical detection. Organic field-effect transistor (OFET) sensors are lightweight, flexible, foldable, and biocompatible with wearable devices. Organic electrochemical transistor (OECT) sensors convert biological signals in body fluids into electrical signals for artificial intelligence analysis. In addition to biochemical markers in body fluids, electrophysiology indicators such as electrocardiogram (ECG) signals and body temperature can also cause changes in the current or voltage of transistor-based biochemical sensors. When modified with sensitive substances, sensors can detect specific analytes, improve sensitivity, broaden the detection range, and reduce the limit of detection (LoD). In this review, we introduce three kinds of transistor-based biochemical sensors: FET, OFET, and OECT. We also discuss the fabrication processes for transistor sources, drains, and gates. Furthermore, we demonstrated three sensor types for body fluid biomarkers, electrophysiology signals, and development trends. Transistor-based biochemical sensors exhibit excellent potential in multi-mode intelligent analysis and are good candidates for the next generation of intelligent point-of-care testing (iPOCT). |
| first_indexed | 2024-03-11T05:12:31Z |
| format | Article |
| id | doaj.art-ea409d37cb03416d80162e469d3af75b |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T05:12:31Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-ea409d37cb03416d80162e469d3af75b2023-11-17T18:31:07ZengMDPI AGBiosensors2079-63742023-04-0113446910.3390/bios13040469Applications of Transistor-Based Biochemical SensorsQiya Gao0Jie Fu1Shuang Li2Dong Ming3Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, ChinaTransistor-based biochemical sensors feature easy integration with electronic circuits and non-invasive real-time detection. They have been widely used in intelligent wearable devices, electronic skins, and biological analyses and have shown broad application prospects in intelligent medical detection. Field-effect transistor (FET) sensors have high sensitivity, reasonable specificity, rapid response, and portability and provide unique signal amplification during biochemical detection. Organic field-effect transistor (OFET) sensors are lightweight, flexible, foldable, and biocompatible with wearable devices. Organic electrochemical transistor (OECT) sensors convert biological signals in body fluids into electrical signals for artificial intelligence analysis. In addition to biochemical markers in body fluids, electrophysiology indicators such as electrocardiogram (ECG) signals and body temperature can also cause changes in the current or voltage of transistor-based biochemical sensors. When modified with sensitive substances, sensors can detect specific analytes, improve sensitivity, broaden the detection range, and reduce the limit of detection (LoD). In this review, we introduce three kinds of transistor-based biochemical sensors: FET, OFET, and OECT. We also discuss the fabrication processes for transistor sources, drains, and gates. Furthermore, we demonstrated three sensor types for body fluid biomarkers, electrophysiology signals, and development trends. Transistor-based biochemical sensors exhibit excellent potential in multi-mode intelligent analysis and are good candidates for the next generation of intelligent point-of-care testing (iPOCT).https://www.mdpi.com/2079-6374/13/4/469biochemical sensorfield-effect transistor (FET)organic field-effect transistor (OFET)organic electrochemical transistor (OECT)intelligent point-of-care testing (iPOCT) |
| spellingShingle | Qiya Gao Jie Fu Shuang Li Dong Ming Applications of Transistor-Based Biochemical Sensors Biosensors biochemical sensor field-effect transistor (FET) organic field-effect transistor (OFET) organic electrochemical transistor (OECT) intelligent point-of-care testing (iPOCT) |
| title | Applications of Transistor-Based Biochemical Sensors |
| title_full | Applications of Transistor-Based Biochemical Sensors |
| title_fullStr | Applications of Transistor-Based Biochemical Sensors |
| title_full_unstemmed | Applications of Transistor-Based Biochemical Sensors |
| title_short | Applications of Transistor-Based Biochemical Sensors |
| title_sort | applications of transistor based biochemical sensors |
| topic | biochemical sensor field-effect transistor (FET) organic field-effect transistor (OFET) organic electrochemical transistor (OECT) intelligent point-of-care testing (iPOCT) |
| url | https://www.mdpi.com/2079-6374/13/4/469 |
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