Ocular surface immune cell diversity in dry eye disease
Dry eye disease (DED) is a multifactorial chronic ocular surface inflammatory condition. Disease severity has been directly related to the immuno-inflammatory status of the ocular surface. Any perturbation in the orchestrated functional harmony between the ocular surface structural cells and immune...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1237;epage=1247;aulast=Nair |
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| author | Archana Padmanabhan Nair Sharon D'Souza Pooja Khamar Rudy M M A Nuijts Swaminathan Sethu Rohit Shetty |
| author_facet | Archana Padmanabhan Nair Sharon D'Souza Pooja Khamar Rudy M M A Nuijts Swaminathan Sethu Rohit Shetty |
| author_sort | Archana Padmanabhan Nair |
| collection | DOAJ |
| description | Dry eye disease (DED) is a multifactorial chronic ocular surface inflammatory condition. Disease severity has been directly related to the immuno-inflammatory status of the ocular surface. Any perturbation in the orchestrated functional harmony between the ocular surface structural cells and immune cells, both resident and trafficking ones, can adversely affect ocular surface health. The diversity and contribution of ocular surface immune cells in DED have been of interest for over a couple of decades. As is true with any mucosal tissue, the ocular surface harbors a variety of immune cells of the innate-adaptive continuum and some of which are altered in DED. The current review curates and organizes the knowledge related to the ocular surface immune cell diversity in DED. Ten different major immune cell types and 21 immune cell subsets have been studied in the context of DED in human subjects and in animal models. The most pertinent observations are increased ocular surface proportions of neutrophils, dendritic cells, macrophages, and T cell subsets (CD4+; CD8+; Th17) along with a decrease in T regulatory cells. Some of these cells have demonstrated disease-causal association with ocular surface health parameters such as OSDI score, Schirmer's test-1, tear break-up time, and corneal staining. The review also summarizes various interventional strategies studied to modulate specific immune cell subsets and reduce DED severity. Further advancements would enable the use of ocular surface immune cell diversity, in patient stratification, i.e. DED-immunotypes, disease monitoring, and selective targeting to resolve the morbidity related to DED. |
| first_indexed | 2024-03-13T10:36:32Z |
| format | Article |
| id | doaj.art-ea424ce8c43945838634c3f2065c61e0 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-13T10:36:32Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-ea424ce8c43945838634c3f2065c61e02023-05-18T05:50:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-017141237124710.4103/IJO.IJO_2986_22Ocular surface immune cell diversity in dry eye diseaseArchana Padmanabhan NairSharon D'SouzaPooja KhamarRudy M M A NuijtsSwaminathan SethuRohit ShettyDry eye disease (DED) is a multifactorial chronic ocular surface inflammatory condition. Disease severity has been directly related to the immuno-inflammatory status of the ocular surface. Any perturbation in the orchestrated functional harmony between the ocular surface structural cells and immune cells, both resident and trafficking ones, can adversely affect ocular surface health. The diversity and contribution of ocular surface immune cells in DED have been of interest for over a couple of decades. As is true with any mucosal tissue, the ocular surface harbors a variety of immune cells of the innate-adaptive continuum and some of which are altered in DED. The current review curates and organizes the knowledge related to the ocular surface immune cell diversity in DED. Ten different major immune cell types and 21 immune cell subsets have been studied in the context of DED in human subjects and in animal models. The most pertinent observations are increased ocular surface proportions of neutrophils, dendritic cells, macrophages, and T cell subsets (CD4+; CD8+; Th17) along with a decrease in T regulatory cells. Some of these cells have demonstrated disease-causal association with ocular surface health parameters such as OSDI score, Schirmer's test-1, tear break-up time, and corneal staining. The review also summarizes various interventional strategies studied to modulate specific immune cell subsets and reduce DED severity. Further advancements would enable the use of ocular surface immune cell diversity, in patient stratification, i.e. DED-immunotypes, disease monitoring, and selective targeting to resolve the morbidity related to DED.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1237;epage=1247;aulast=Nairdendritic cellsdry eye diseaseimmune cellsneutrophilsocular surfaceocular surface washt cells |
| spellingShingle | Archana Padmanabhan Nair Sharon D'Souza Pooja Khamar Rudy M M A Nuijts Swaminathan Sethu Rohit Shetty Ocular surface immune cell diversity in dry eye disease Indian Journal of Ophthalmology dendritic cells dry eye disease immune cells neutrophils ocular surface ocular surface wash t cells |
| title | Ocular surface immune cell diversity in dry eye disease |
| title_full | Ocular surface immune cell diversity in dry eye disease |
| title_fullStr | Ocular surface immune cell diversity in dry eye disease |
| title_full_unstemmed | Ocular surface immune cell diversity in dry eye disease |
| title_short | Ocular surface immune cell diversity in dry eye disease |
| title_sort | ocular surface immune cell diversity in dry eye disease |
| topic | dendritic cells dry eye disease immune cells neutrophils ocular surface ocular surface wash t cells |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1237;epage=1247;aulast=Nair |
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