Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy

Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy

Neural circuits underlying brain functions are vulnerable to damage, including ischemic injury, leading to neuronal loss and gliosis. Recent technology of direct conversion of endogenous astrocytes into neurons in situ can simultaneously replenish the neuronal population and reverse the glial scar....

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Bibliographic Details
Main Authors: Yu Tang, Qiuyu Wu, Mang Gao, Esther Ryu, Zifei Pei, Samuel T. Kissinger, Yuchen Chen, Abhinav K. Rao, Zongqin Xiang, Tao Wang, Wen Li, Gong Chen, Alexander A. Chubykin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NeuroD1
gene therapy
functional circuit recovery
ischemic injury
visual cortex
circuit mapping
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.720078/full

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