Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota
Postprandial hyperglycemia increases the risk of mortality among patients with type 2 diabetes and cardiovascular diseases. Additionally, the gut microbiota and type 2 diabetes and cardio-vascular disease are known to be correlated. Currently, fasting blood glucose is the primary in-dex for the clin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/7/669 |
| _version_ | 1797445237377859584 |
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| author | Yui Mineshita Hiroyuki Sasaki Hyeon-ki Kim Shigenobu Shibata |
| author_facet | Yui Mineshita Hiroyuki Sasaki Hyeon-ki Kim Shigenobu Shibata |
| author_sort | Yui Mineshita |
| collection | DOAJ |
| description | Postprandial hyperglycemia increases the risk of mortality among patients with type 2 diabetes and cardiovascular diseases. Additionally, the gut microbiota and type 2 diabetes and cardio-vascular disease are known to be correlated. Currently, fasting blood glucose is the primary in-dex for the clinical diagnosis of diabetes; however, postprandial blood glucose is associated with the risk of developing type 2 diabetes and cardiovascular disease and mortality. Therefore, the dynamic change in blood glucose levels under free-living conditions is considered an important and better marker than fasting glucose levels to study the relationship between glucose levels and microbiota. Here, we investigated the relationship between fasting and postprandial glucose levels and microbiota under free-living conditions for one week in older adults. In addition, in order to clarify the relationship between blood glucose level and intestinal bacteria, postprandial 4-h AUC was calculated and the correlation with gut bacteria was investigated. As a result of the present study, we observed many of the most significant correlations between the gut bacteria and the peak glucose levels after dinner and the 4-h AUC after dinner. Together, these findings suggest that the individual pattern of microbiota may help to predict post-dinner hyperglycemia and the risk of abnormal glucose metabolism, such as diabetes. |
| first_indexed | 2024-03-09T13:23:51Z |
| format | Article |
| id | doaj.art-ea4349adc69b4322bd344b04bd3761fa |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T13:23:51Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ea4349adc69b4322bd344b04bd3761fa2023-11-30T21:27:34ZengMDPI AGMetabolites2218-19892022-07-0112766910.3390/metabo12070669Relationship between Fasting and Postprandial Glucose Levels and the Gut MicrobiotaYui Mineshita0Hiroyuki Sasaki1Hyeon-ki Kim2Shigenobu Shibata3Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo 162-0056, JapanLaboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo 162-0056, JapanLaboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo 162-0056, JapanLaboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo 162-0056, JapanPostprandial hyperglycemia increases the risk of mortality among patients with type 2 diabetes and cardiovascular diseases. Additionally, the gut microbiota and type 2 diabetes and cardio-vascular disease are known to be correlated. Currently, fasting blood glucose is the primary in-dex for the clinical diagnosis of diabetes; however, postprandial blood glucose is associated with the risk of developing type 2 diabetes and cardiovascular disease and mortality. Therefore, the dynamic change in blood glucose levels under free-living conditions is considered an important and better marker than fasting glucose levels to study the relationship between glucose levels and microbiota. Here, we investigated the relationship between fasting and postprandial glucose levels and microbiota under free-living conditions for one week in older adults. In addition, in order to clarify the relationship between blood glucose level and intestinal bacteria, postprandial 4-h AUC was calculated and the correlation with gut bacteria was investigated. As a result of the present study, we observed many of the most significant correlations between the gut bacteria and the peak glucose levels after dinner and the 4-h AUC after dinner. Together, these findings suggest that the individual pattern of microbiota may help to predict post-dinner hyperglycemia and the risk of abnormal glucose metabolism, such as diabetes.https://www.mdpi.com/2218-1989/12/7/669postprandial hyperglycemiagut microbiotapostprandial blood glucose |
| spellingShingle | Yui Mineshita Hiroyuki Sasaki Hyeon-ki Kim Shigenobu Shibata Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota Metabolites postprandial hyperglycemia gut microbiota postprandial blood glucose |
| title | Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota |
| title_full | Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota |
| title_fullStr | Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota |
| title_full_unstemmed | Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota |
| title_short | Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota |
| title_sort | relationship between fasting and postprandial glucose levels and the gut microbiota |
| topic | postprandial hyperglycemia gut microbiota postprandial blood glucose |
| url | https://www.mdpi.com/2218-1989/12/7/669 |
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