Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension
Findings of the available studies regarding the roles of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in hypertension are inconsistent, conflicting and inconclusive. The purpose of this study was to explore and clarify the existence of any relationships of individual BCAAs and...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3791 |
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| author | M. H. Mahbub Natsu Yamaguchi Ryosuke Hase Hidekazu Takahashi Yasutaka Ishimaru Rie Watanabe Hiroyuki Saito Junki Shimokawa Hiroshi Yamamoto Shinya Kikuchi Tsuyoshi Tanabe |
| author_facet | M. H. Mahbub Natsu Yamaguchi Ryosuke Hase Hidekazu Takahashi Yasutaka Ishimaru Rie Watanabe Hiroyuki Saito Junki Shimokawa Hiroshi Yamamoto Shinya Kikuchi Tsuyoshi Tanabe |
| author_sort | M. H. Mahbub |
| collection | DOAJ |
| description | Findings of the available studies regarding the roles of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in hypertension are inconsistent, conflicting and inconclusive. The purpose of this study was to explore and clarify the existence of any relationships of individual BCAAs and AAAs with hypertension with adjustments for potential relevant confounders. A total of 2805 healthy controls and 2736 hypertensive patients were included in the current analysis. The associations between individual amino acids and hypertension were explored by logistic regression analyses adjusted for potential confounding variables. Among the investigated amino acids, only the BCAAs showed consistently significant positive associations with hypertension in the adjusted models (<i>p</i>-trend < 0.05 to 0.001). However, compared with the corresponding lowest quartile of individual BCAAs, the positive association with hypertension remained significant only in the highest quartile (<i>p</i> < 0.01 to 0.001). We confirmed in a relatively large cohort of subjects that BCAAs, not AAAs, demonstrated consistent positive associations with hypertension. The results display the promising potential for the use of BCAAs as relevant and accessible biomarkers, and provide perspectives on interventions directed towards the reduction in plasma BCAA levels in the prevention and management of hypertension. |
| first_indexed | 2024-03-10T14:10:15Z |
| format | Article |
| id | doaj.art-ea4462b29e064139a5b8bb045c3d5900 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:10:15Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ea4462b29e064139a5b8bb045c3d59002023-11-21T00:15:49ZengMDPI AGNutrients2072-66432020-12-011212379110.3390/nu12123791Plasma Branched-Chain and Aromatic Amino Acids in Relation to HypertensionM. H. Mahbub0Natsu Yamaguchi1Ryosuke Hase2Hidekazu Takahashi3Yasutaka Ishimaru4Rie Watanabe5Hiroyuki Saito6Junki Shimokawa7Hiroshi Yamamoto8Shinya Kikuchi9Tsuyoshi Tanabe10Department of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanDepartment of Public Health, Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime 794-8555, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanInstitute for Innovation, Ajinomoto Co. Inc., Kawasaki, Kanagawa 210-8681, JapanInstitute for Innovation, Ajinomoto Co. Inc., Kawasaki, Kanagawa 210-8681, JapanDepartment of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, JapanFindings of the available studies regarding the roles of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in hypertension are inconsistent, conflicting and inconclusive. The purpose of this study was to explore and clarify the existence of any relationships of individual BCAAs and AAAs with hypertension with adjustments for potential relevant confounders. A total of 2805 healthy controls and 2736 hypertensive patients were included in the current analysis. The associations between individual amino acids and hypertension were explored by logistic regression analyses adjusted for potential confounding variables. Among the investigated amino acids, only the BCAAs showed consistently significant positive associations with hypertension in the adjusted models (<i>p</i>-trend < 0.05 to 0.001). However, compared with the corresponding lowest quartile of individual BCAAs, the positive association with hypertension remained significant only in the highest quartile (<i>p</i> < 0.01 to 0.001). We confirmed in a relatively large cohort of subjects that BCAAs, not AAAs, demonstrated consistent positive associations with hypertension. The results display the promising potential for the use of BCAAs as relevant and accessible biomarkers, and provide perspectives on interventions directed towards the reduction in plasma BCAA levels in the prevention and management of hypertension.https://www.mdpi.com/2072-6643/12/12/3791plasma amino acidsbranched-chainaromatichypertension |
| spellingShingle | M. H. Mahbub Natsu Yamaguchi Ryosuke Hase Hidekazu Takahashi Yasutaka Ishimaru Rie Watanabe Hiroyuki Saito Junki Shimokawa Hiroshi Yamamoto Shinya Kikuchi Tsuyoshi Tanabe Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension Nutrients plasma amino acids branched-chain aromatic hypertension |
| title | Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension |
| title_full | Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension |
| title_fullStr | Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension |
| title_full_unstemmed | Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension |
| title_short | Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension |
| title_sort | plasma branched chain and aromatic amino acids in relation to hypertension |
| topic | plasma amino acids branched-chain aromatic hypertension |
| url | https://www.mdpi.com/2072-6643/12/12/3791 |
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