An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages

An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages

Summary: ECSIT is a mitochondrial complex I (CI)-associated protein that has been shown to regulate the production of mitochondrial reactive oxygen species (mROS) following engagement of Toll-like receptors (TLRs). We have generated an Ecsit conditional knockout (CKO) mouse strain to study the in vi...

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Bibliographic Details
Main Authors: Flávia R.G. Carneiro, Alice Lepelley, John J. Seeley, Matthew S. Hayden, Sankar Ghosh
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718302328

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