Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy.
Antipsychotic medications are increasingly used during pregnancy. Nevertheless, fetal risks are still not fully studied. It is currently unclear whether the antipsychotic treatment might induce a higher risk of fetal death. We aimed to determine if use of antipsychotic medication during pregnancy is...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4498617?pdf=render |
| _version_ | 1811242462315806720 |
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| author | Merete Juul Sørensen Maiken Ina Siegismund Kjaersgaard Henrik Søndergaard Pedersen Mogens Vestergaard Jacob Christensen Jørn Olsen Erik Parner Lars Henning Pedersen Bodil Hammer Bech |
| author_facet | Merete Juul Sørensen Maiken Ina Siegismund Kjaersgaard Henrik Søndergaard Pedersen Mogens Vestergaard Jacob Christensen Jørn Olsen Erik Parner Lars Henning Pedersen Bodil Hammer Bech |
| author_sort | Merete Juul Sørensen |
| collection | DOAJ |
| description | Antipsychotic medications are increasingly used during pregnancy. Nevertheless, fetal risks are still not fully studied. It is currently unclear whether the antipsychotic treatment might induce a higher risk of fetal death. We aimed to determine if use of antipsychotic medication during pregnancy is associated with an increased risk of spontaneous abortion or stillbirth.In a historical cohort study, we identified all clinically recognized pregnancies registered in the nationwide Danish registries from 1997 to 2008 (N = 1,005,319). Exposure was defined as any prescription of antipsychotic medications redeemed by the pregnant women during the exposure window, and recorded in the Danish National Prescription Register. Outcome was defined as any spontaneous abortion or stillbirth recorded in the Danish National Hospital Register and the Danish Medical Birth Register respectively.Women exposed to antipsychotic medications during pregnancy had a 34% higher risk of spontaneous abortion (adjusted relative risk = 1.34; 95% confidence interval = 1.22; 1.46) compared to unexposed women, but a similar risk compared to women exposed prior to (but not during) pregnancy (adjusted relative risk = 1.04; 95% confidence interval = 0.93; 1.17). The risk of spontaneous abortion was not increased in exposed pregnancies when compared to unexposed pregnancies in the same women (adjusted hazard ratio = 1.11; 95% CI = 0.94; 1.31). A twofold higher risk of stillbirth was found in women exposed to antipsychotic medications compared with unexposed women (relative risk = 2.27; 95% confidence interval = 1.45; 3.55) and compared with women exposed only prior to pregnancy (relative risk = 2.06; 95% confidence interval = 1.01; 4.19).The increased risk of spontaneous abortion found in women treated with antipsychotic medications during pregnancy is most likely due to confounding factors. The risk of stillbirth was twofold higher in pregnancies exposed to antipsychotic medication during pregnancy. Treatment with antipsychotic medications during pregnancy requires careful consideration. |
| first_indexed | 2024-04-12T13:51:38Z |
| format | Article |
| id | doaj.art-ea455b84db2b4424bbe93f8783b95724 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T13:51:38Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ea455b84db2b4424bbe93f8783b957242022-12-22T03:30:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013228010.1371/journal.pone.0132280Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy.Merete Juul SørensenMaiken Ina Siegismund KjaersgaardHenrik Søndergaard PedersenMogens VestergaardJacob ChristensenJørn OlsenErik ParnerLars Henning PedersenBodil Hammer BechAntipsychotic medications are increasingly used during pregnancy. Nevertheless, fetal risks are still not fully studied. It is currently unclear whether the antipsychotic treatment might induce a higher risk of fetal death. We aimed to determine if use of antipsychotic medication during pregnancy is associated with an increased risk of spontaneous abortion or stillbirth.In a historical cohort study, we identified all clinically recognized pregnancies registered in the nationwide Danish registries from 1997 to 2008 (N = 1,005,319). Exposure was defined as any prescription of antipsychotic medications redeemed by the pregnant women during the exposure window, and recorded in the Danish National Prescription Register. Outcome was defined as any spontaneous abortion or stillbirth recorded in the Danish National Hospital Register and the Danish Medical Birth Register respectively.Women exposed to antipsychotic medications during pregnancy had a 34% higher risk of spontaneous abortion (adjusted relative risk = 1.34; 95% confidence interval = 1.22; 1.46) compared to unexposed women, but a similar risk compared to women exposed prior to (but not during) pregnancy (adjusted relative risk = 1.04; 95% confidence interval = 0.93; 1.17). The risk of spontaneous abortion was not increased in exposed pregnancies when compared to unexposed pregnancies in the same women (adjusted hazard ratio = 1.11; 95% CI = 0.94; 1.31). A twofold higher risk of stillbirth was found in women exposed to antipsychotic medications compared with unexposed women (relative risk = 2.27; 95% confidence interval = 1.45; 3.55) and compared with women exposed only prior to pregnancy (relative risk = 2.06; 95% confidence interval = 1.01; 4.19).The increased risk of spontaneous abortion found in women treated with antipsychotic medications during pregnancy is most likely due to confounding factors. The risk of stillbirth was twofold higher in pregnancies exposed to antipsychotic medication during pregnancy. Treatment with antipsychotic medications during pregnancy requires careful consideration.http://europepmc.org/articles/PMC4498617?pdf=render |
| spellingShingle | Merete Juul Sørensen Maiken Ina Siegismund Kjaersgaard Henrik Søndergaard Pedersen Mogens Vestergaard Jacob Christensen Jørn Olsen Erik Parner Lars Henning Pedersen Bodil Hammer Bech Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy. PLoS ONE |
| title | Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy. |
| title_full | Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy. |
| title_fullStr | Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy. |
| title_full_unstemmed | Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy. |
| title_short | Risk of Fetal Death after Treatment with Antipsychotic Medications during Pregnancy. |
| title_sort | risk of fetal death after treatment with antipsychotic medications during pregnancy |
| url | http://europepmc.org/articles/PMC4498617?pdf=render |
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