Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity
Abstract Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different varia...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-85676-7 |
| _version_ | 1818402881497202688 |
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| author | María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe Ryoko Machida-Hirano Jorge David Cadena-Zamudio |
| author_facet | María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe Ryoko Machida-Hirano Jorge David Cadena-Zamudio |
| author_sort | María Isabel Iñiguez-Luna |
| collection | DOAJ |
| description | Abstract Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered using NTSYSpc software where 30 showed a Pearson correlation (> 0.5) and nine variables (< 0.05), Finally, using a cladistics analysis approach highlighted 65 genetic bands, in addition to color of the fruit, presence of thorns, bitter flavor, piriform and oblong shape, and also content of chlorophylls a and b, presence of cucurbitacins, and the IC50 effect of chayote extracts on the four cell lines. |
| first_indexed | 2024-12-14T08:15:24Z |
| format | Article |
| id | doaj.art-ea47dcfc08d04505ba7322703ac04791 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:15:24Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ea47dcfc08d04505ba7322703ac047912022-12-21T23:09:57ZengNature PortfolioScientific Reports2045-23222021-03-0111111210.1038/s41598-021-85676-7Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activityMaría Isabel Iñiguez-Luna0Jorge Cadena-Iñiguez1Ramón Marcos Soto-Hernández2Francisco Javier Morales-Flores3Moisés Cortes-Cruz4Kazuo N. Watanabe5Ryoko Machida-Hirano6Jorge David Cadena-Zamudio7Postgrado de Innovación en Manejo de Recursos Naturales Colegio de PosgraduadosPostgrado de Innovación en Manejo de Recursos Naturales Colegio de PosgraduadosPrograma de Botánica Colegio de PostgraduadosPostgrado de Innovación en Manejo de Recursos Naturales Colegio de PosgraduadosCentro Nacional de Recursos Genéticos-INIFAPTsukuba Plant Innovation Research Center, University of TsukubaGenetic Resources Center, National Agriculture and Food Research OrganizationGrupo Interdisciplinario de Investigación en Sechium edule en MéxicoAbstract Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered using NTSYSpc software where 30 showed a Pearson correlation (> 0.5) and nine variables (< 0.05), Finally, using a cladistics analysis approach highlighted 65 genetic bands, in addition to color of the fruit, presence of thorns, bitter flavor, piriform and oblong shape, and also content of chlorophylls a and b, presence of cucurbitacins, and the IC50 effect of chayote extracts on the four cell lines.https://doi.org/10.1038/s41598-021-85676-7 |
| spellingShingle | María Isabel Iñiguez-Luna Jorge Cadena-Iñiguez Ramón Marcos Soto-Hernández Francisco Javier Morales-Flores Moisés Cortes-Cruz Kazuo N. Watanabe Ryoko Machida-Hirano Jorge David Cadena-Zamudio Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity Scientific Reports |
| title | Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity |
| title_full | Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity |
| title_fullStr | Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity |
| title_full_unstemmed | Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity |
| title_short | Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity |
| title_sort | bioprospecting of sechium spp varieties for the selection of characters with pharmacological activity |
| url | https://doi.org/10.1038/s41598-021-85676-7 |
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