Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies
Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/9/2168 |
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| author | Ibrahim N. Amirrah Mohd Farhanulhakim Mohd Razip Wee Yasuhiko Tabata Ruszymah Bt Hj Idrus Abid Nordin Mh Busra Fauzi |
| author_facet | Ibrahim N. Amirrah Mohd Farhanulhakim Mohd Razip Wee Yasuhiko Tabata Ruszymah Bt Hj Idrus Abid Nordin Mh Busra Fauzi |
| author_sort | Ibrahim N. Amirrah |
| collection | DOAJ |
| description | Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (<i>n</i>) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (<i>n</i> = 2), gentamicin (<i>n</i> = 3), combined-cellulose and silver (<i>n</i> = 1), gentian violet/methylene blue mixed (<i>n</i> = 1), and silver (<i>n</i> = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency. |
| first_indexed | 2024-03-10T16:08:13Z |
| format | Article |
| id | doaj.art-ea494f8e746b4721b90b3feef3151707 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T16:08:13Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ea494f8e746b4721b90b3feef31517072023-11-20T14:42:01ZengMDPI AGPolymers2073-43602020-09-01129216810.3390/polym12092168Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical StudiesIbrahim N. Amirrah0Mohd Farhanulhakim Mohd Razip Wee1Yasuhiko Tabata2Ruszymah Bt Hj Idrus3Abid Nordin4Mh Busra Fauzi5Centre for Tissue Engineering and Regenerative Medicine, UKM Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaInstitute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, MalaysiaLaboratory of Biomaterials, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8397, JapanCentre for Tissue Engineering and Regenerative Medicine, UKM Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, UKM Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaDiabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (<i>n</i>) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (<i>n</i> = 2), gentamicin (<i>n</i> = 3), combined-cellulose and silver (<i>n</i> = 1), gentian violet/methylene blue mixed (<i>n</i> = 1), and silver (<i>n</i> = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.https://www.mdpi.com/2073-4360/12/9/2168antibacterialdiabetic ulcercollagenwound dressingwound healingclinical trial |
| spellingShingle | Ibrahim N. Amirrah Mohd Farhanulhakim Mohd Razip Wee Yasuhiko Tabata Ruszymah Bt Hj Idrus Abid Nordin Mh Busra Fauzi Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies Polymers antibacterial diabetic ulcer collagen wound dressing wound healing clinical trial |
| title | Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies |
| title_full | Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies |
| title_fullStr | Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies |
| title_full_unstemmed | Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies |
| title_short | Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies |
| title_sort | antibacterial integrated collagen wound dressing for diabetes related foot ulcers an evidence based review of clinical studies |
| topic | antibacterial diabetic ulcer collagen wound dressing wound healing clinical trial |
| url | https://www.mdpi.com/2073-4360/12/9/2168 |
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