Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress

Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress

<p>Abstract</p> <p>Background</p> <p>The finite replicative lifespan of cells, termed cellular senescence, has been proposed as a protective mechanism against the proliferation of oncogenically damaged cells, that fuel cancer. This concept is further supported by the in...

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Bibliographic Details
Main Authors: Lafontaine Julie, Tchakarska Guergana, Rodier Francis, Mes-Masson Anne-Marie
Format: Article
Language:English
Published: BMC 2012-06-01
Series:BMC Cancer
Subjects:
Necdin
p53
Senescence
Radioresistance
IMR90
Online Access:http://www.biomedcentral.com/1471-2407/12/234

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