Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases
Abstract Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to cognitive impairment and dyskinesias. It is now well recognized that molecular events precede the onset of clinical...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40035-023-00339-z |
| _version_ | 1811165804909035520 |
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| author | Vaibhav Sharma Fredrik Nikolajeff Saroj Kumar |
| author_facet | Vaibhav Sharma Fredrik Nikolajeff Saroj Kumar |
| author_sort | Vaibhav Sharma |
| collection | DOAJ |
| description | Abstract Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to cognitive impairment and dyskinesias. It is now well recognized that molecular events precede the onset of clinical symptoms by years. Over the past decade, intensive research attempts have been aimed at the early diagnosis of these diseases. Recently, exosomes have been shown to play a pivotal role in the occurrence and progression of many diseases including cancer and neurodegenerative diseases. Additionally, because exosomes can cross the blood–brain barrier, they may serve as a diagnostic tool for neural dysfunction. In this review, we detail the mechanisms and current challenges of these diseases, briefly review the role of exosomes in the progression of neurodegenerative diseases, and propose a novel strategy based on salivary neuronal exosomes and nanoparticle tracking analysis that could be employed for screening the early onset of neurodegenerative diseases. |
| first_indexed | 2024-04-10T15:42:34Z |
| format | Article |
| id | doaj.art-ea4b260f3aba4dd4808e0a8a101e3644 |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-04-10T15:42:34Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-ea4b260f3aba4dd4808e0a8a101e36442023-02-12T12:20:34ZengBMCTranslational Neurodegeneration2047-91582023-02-0112111010.1186/s40035-023-00339-zEmploying nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseasesVaibhav Sharma0Fredrik Nikolajeff1Saroj Kumar2Department of Health, Education and Technology, Lulea University of TechnologyDepartment of Health, Education and Technology, Lulea University of TechnologyDepartment of Health, Education and Technology, Lulea University of TechnologyAbstract Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to cognitive impairment and dyskinesias. It is now well recognized that molecular events precede the onset of clinical symptoms by years. Over the past decade, intensive research attempts have been aimed at the early diagnosis of these diseases. Recently, exosomes have been shown to play a pivotal role in the occurrence and progression of many diseases including cancer and neurodegenerative diseases. Additionally, because exosomes can cross the blood–brain barrier, they may serve as a diagnostic tool for neural dysfunction. In this review, we detail the mechanisms and current challenges of these diseases, briefly review the role of exosomes in the progression of neurodegenerative diseases, and propose a novel strategy based on salivary neuronal exosomes and nanoparticle tracking analysis that could be employed for screening the early onset of neurodegenerative diseases.https://doi.org/10.1186/s40035-023-00339-zExosomesParkinson’s diseaseAlzheimer’s diseaseNeurodegenerative diseaseDiagnosisPrognosis |
| spellingShingle | Vaibhav Sharma Fredrik Nikolajeff Saroj Kumar Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases Translational Neurodegeneration Exosomes Parkinson’s disease Alzheimer’s disease Neurodegenerative disease Diagnosis Prognosis |
| title | Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases |
| title_full | Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases |
| title_fullStr | Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases |
| title_full_unstemmed | Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases |
| title_short | Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases |
| title_sort | employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases |
| topic | Exosomes Parkinson’s disease Alzheimer’s disease Neurodegenerative disease Diagnosis Prognosis |
| url | https://doi.org/10.1186/s40035-023-00339-z |
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