Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015
Respiratory syncytial viruses (RSV) including subgroups A (RSV-A) and B (RSV-B) are an important cause of acute respiratory tract infections worldwide. RSV-A include major epidemic strains. Fundamental questions concerning the evolution, persistence and transmission of RSV-A are critical for disease...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-08-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01263/full |
| _version_ | 1811316506423721984 |
|---|---|
| author | Jing Lu Lirong Zhou lina Yi Jie Wu Yingchao Song Guofeng Huang Xin Zhang lijun liang hanzhong Ni Oliver Pybus Changwen Ke |
| author_facet | Jing Lu Lirong Zhou lina Yi Jie Wu Yingchao Song Guofeng Huang Xin Zhang lijun liang hanzhong Ni Oliver Pybus Changwen Ke |
| author_sort | Jing Lu |
| collection | DOAJ |
| description | Respiratory syncytial viruses (RSV) including subgroups A (RSV-A) and B (RSV-B) are an important cause of acute respiratory tract infections worldwide. RSV-A include major epidemic strains. Fundamental questions concerning the evolution, persistence and transmission of RSV-A are critical for disease control and prevention, yet remain unanswered. In this study, we generated 64 complete G gene sequences of RSV-A strains collected between 2008 and 2015 in Guangdong, China. Phylogenetic analysis was undertaken by incorporating 572 publicly available RSV-A sequences. Current data indicate that genotypes GA1, GA4 and GA5 are endemic with limited epidemic activity. In contrast, the GA2 genotype which likely originated in 1980 has spread rapidly and caused epidemics worldwide. By analyzing GA2 genotype sequences across epidemic seasons within Guangdong, we find that RSV-A epidemics in Guangdong are caused by a combination of virus importation and local persistence, although the magnitude of the latter is likely overestimated due to infrequent sampling in other regions. Our results provide new insights into RSV-A evolution and transmission at global and local scales and highlights the rapid and wide spread of genotype GA2 compared to other genotypes. In order to control RSV transmission and outbreak, both local persistence and external introduction should be taken into account when designing optimal strategies |
| first_indexed | 2024-04-13T11:51:07Z |
| format | Article |
| id | doaj.art-ea4d1f0de60145758b6ab81bf6f3e712 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T11:51:07Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ea4d1f0de60145758b6ab81bf6f3e7122022-12-22T02:48:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-08-01710.3389/fmicb.2016.01263215617Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015Jing Lu0Lirong Zhou1lina Yi2Jie Wu3Yingchao Song4Guofeng Huang5Xin Zhang6lijun liang7hanzhong Ni8Oliver Pybus9Changwen Ke10GDCDCGDCDCGDCDCGDCDCGDCDCGDCDCGDCDCGDCDCGDCDCUniversity of OxfordGDCDCRespiratory syncytial viruses (RSV) including subgroups A (RSV-A) and B (RSV-B) are an important cause of acute respiratory tract infections worldwide. RSV-A include major epidemic strains. Fundamental questions concerning the evolution, persistence and transmission of RSV-A are critical for disease control and prevention, yet remain unanswered. In this study, we generated 64 complete G gene sequences of RSV-A strains collected between 2008 and 2015 in Guangdong, China. Phylogenetic analysis was undertaken by incorporating 572 publicly available RSV-A sequences. Current data indicate that genotypes GA1, GA4 and GA5 are endemic with limited epidemic activity. In contrast, the GA2 genotype which likely originated in 1980 has spread rapidly and caused epidemics worldwide. By analyzing GA2 genotype sequences across epidemic seasons within Guangdong, we find that RSV-A epidemics in Guangdong are caused by a combination of virus importation and local persistence, although the magnitude of the latter is likely overestimated due to infrequent sampling in other regions. Our results provide new insights into RSV-A evolution and transmission at global and local scales and highlights the rapid and wide spread of genotype GA2 compared to other genotypes. In order to control RSV transmission and outbreak, both local persistence and external introduction should be taken into account when designing optimal strategieshttp://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01263/fullevolutionphylogenetictransmissionrespiratory syncytial virusPhylogeographic |
| spellingShingle | Jing Lu Lirong Zhou lina Yi Jie Wu Yingchao Song Guofeng Huang Xin Zhang lijun liang hanzhong Ni Oliver Pybus Changwen Ke Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015 Frontiers in Microbiology evolution phylogenetic transmission respiratory syncytial virus Phylogeographic |
| title | Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015 |
| title_full | Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015 |
| title_fullStr | Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015 |
| title_full_unstemmed | Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015 |
| title_short | Evolution and Transmission of Respiratory Syncytial Group A (RSV-A) Viruses in Guangdong, China 2008-2015 |
| title_sort | evolution and transmission of respiratory syncytial group a rsv a viruses in guangdong china 2008 2015 |
| topic | evolution phylogenetic transmission respiratory syncytial virus Phylogeographic |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01263/full |
| work_keys_str_mv | AT jinglu evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT lirongzhou evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT linayi evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT jiewu evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT yingchaosong evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT guofenghuang evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT xinzhang evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT lijunliang evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT hanzhongni evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT oliverpybus evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 AT changwenke evolutionandtransmissionofrespiratorysyncytialgrouparsvavirusesinguangdongchina20082015 |