DRP1 Inhibition Enhances Venetoclax-Induced Mitochondrial Apoptosis in TP53-Mutated Acute Myeloid Leukemia Cells through BAX/BAK Activation

DRP1 Inhibition Enhances Venetoclax-Induced Mitochondrial Apoptosis in TP53-Mutated Acute Myeloid Leukemia Cells through BAX/BAK Activation

Although TP53 mutations in acute myeloid leukemia (AML) are associated with poor response to venetoclax, the underlying resistance mechanism remains unclear. Herein, we investigated the functional role of dynamin-related protein 1 (DRP1) in venetoclax sensitivity in AML cells with respect to TP53 mu...

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Bibliographic Details
Main Authors: Ji Eun Jang, Doh Yu Hwang, Ju-In Eom, June-Won Cheong, Hoi-Kyung Jeung, Hyunsoo Cho, Haerim Chung, Jin Seok Kim, Yoo Hong Min
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
TP53 mutation
DRP1 inhibition
venetoclax resistance
mitochondrial apoptosis
acute myeloid leukemia
Online Access:https://www.mdpi.com/2072-6694/15/3/745

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