Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome
Background: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most common cause of uterine aplasia, with a worldwide frequency of 1 in 4500 females. Although abundant literature is present regarding the different available methods for creating a neovagina in MRKH syndrome, the attention dedi...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.2442 |
| _version_ | 1818005891455123456 |
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| author | Francesco Fedele Alessandro Bulfoni Stefano Salvatore Massimo Candiani |
| author_facet | Francesco Fedele Alessandro Bulfoni Stefano Salvatore Massimo Candiani |
| author_sort | Francesco Fedele |
| collection | DOAJ |
| description | Background: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most common cause of uterine aplasia, with a worldwide frequency of 1 in 4500 females. Although abundant literature is present regarding the different available methods for creating a neovagina in MRKH syndrome, the attention dedicated to these women’s reproductive potential remains insufficient. Methods: Online searches were carried out in PubMed database during November and December 2020. The search included a combination of the various terms (e.g., MRKH, vaginoplasty, uterus transplantation, infertility treatment, gestational surrogacy, etc.). The following inclusion criteria were used: (1) The articles should be written in English or French language. (2) The article should have been published by an official scientific organization. Results: Until few years ago, the only option for women with MRKH syndrome was legal adoption, now gestational surrogacy (GS) and uterine transplantation (UTx) have become new fertility options available to these patients. Discussion: GS is officially recognized in several countries and widely practiced. On the other hand, UTx, although the great recent technical improvements, is far from being an option for all women with MRKH syndrome secondary to its complexity and the necessary immunologic therapies. |
| first_indexed | 2024-04-14T04:52:34Z |
| format | Article |
| id | doaj.art-ea52da71e4df4908bbc7da0b6319e31d |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-14T04:52:34Z |
| publishDate | 2021-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-ea52da71e4df4908bbc7da0b6319e31d2022-12-22T02:11:15ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-06-0148345346010.31083/j.ceog.2021.03.2442S0390-6663(21)00109-3Fertility options in Mayer-Rokitansky-Küster-Hauser syndromeFrancesco Fedele0Alessandro Bulfoni1Stefano Salvatore2Massimo Candiani3Obstetrics and Gynaecology Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyDepartment of Gynaecology, Division of Obstetrics and Gynaecology, IRCCS Humanitas Clinical and Research Center, San Pio X, 20089 Milan, ItalyObstetrics and Gynaecology Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynaecology Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyBackground: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most common cause of uterine aplasia, with a worldwide frequency of 1 in 4500 females. Although abundant literature is present regarding the different available methods for creating a neovagina in MRKH syndrome, the attention dedicated to these women’s reproductive potential remains insufficient. Methods: Online searches were carried out in PubMed database during November and December 2020. The search included a combination of the various terms (e.g., MRKH, vaginoplasty, uterus transplantation, infertility treatment, gestational surrogacy, etc.). The following inclusion criteria were used: (1) The articles should be written in English or French language. (2) The article should have been published by an official scientific organization. Results: Until few years ago, the only option for women with MRKH syndrome was legal adoption, now gestational surrogacy (GS) and uterine transplantation (UTx) have become new fertility options available to these patients. Discussion: GS is officially recognized in several countries and widely practiced. On the other hand, UTx, although the great recent technical improvements, is far from being an option for all women with MRKH syndrome secondary to its complexity and the necessary immunologic therapies.https://www.imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.2442mayer-rokitansky-küster-hauser syndromeassisted reproductive technologygestational surrogacyuterus transplantation |
| spellingShingle | Francesco Fedele Alessandro Bulfoni Stefano Salvatore Massimo Candiani Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome Clinical and Experimental Obstetrics & Gynecology mayer-rokitansky-küster-hauser syndrome assisted reproductive technology gestational surrogacy uterus transplantation |
| title | Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome |
| title_full | Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome |
| title_fullStr | Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome |
| title_full_unstemmed | Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome |
| title_short | Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome |
| title_sort | fertility options in mayer rokitansky kuster hauser syndrome |
| topic | mayer-rokitansky-küster-hauser syndrome assisted reproductive technology gestational surrogacy uterus transplantation |
| url | https://www.imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.2442 |
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