Chemical composition and biological activity of Baccharis erioclada DC. essential oil
Abstract The chemically complex essential oils of Baccharis species are associated with several biological activities, such as antimicrobial and antiulcerous properties. However, few studies have investigated Baccharis erioclada DC. Therefore, in this study, we aimed to characterize the essential oi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2022-05-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100571&lng=en&tlng=en |
| _version_ | 1828748372889042944 |
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| author | Vanessa Barbosa Bobek Luiza Stolz Cruz Camila Freitas de Oliveira Fernando Cesar Martins Betim Juliane Nadal Dias Swiech Daniela Gaspardo Folquitto Carmen Antonia Sanches Ito Jane Manfron Budel Sandra Maria Warumby Zanin Josiane de Fátima Padilha de Paula Obdúlio Gomes Miguel |
| author_facet | Vanessa Barbosa Bobek Luiza Stolz Cruz Camila Freitas de Oliveira Fernando Cesar Martins Betim Juliane Nadal Dias Swiech Daniela Gaspardo Folquitto Carmen Antonia Sanches Ito Jane Manfron Budel Sandra Maria Warumby Zanin Josiane de Fátima Padilha de Paula Obdúlio Gomes Miguel |
| author_sort | Vanessa Barbosa Bobek |
| collection | DOAJ |
| description | Abstract The chemically complex essential oils of Baccharis species are associated with several biological activities, such as antimicrobial and antiulcerous properties. However, few studies have investigated Baccharis erioclada DC. Therefore, in this study, we aimed to characterize the essential oil of B. erioclada and evaluate its antioxidant, antimicrobial, and hemolytic potential. The essential oil was extracted by hydrodistillation using a Clevenger apparatus and analyzed via gas chromatography-mass spectrometry (GC-MS). Phosphomolybdenum complex formation, reducing antioxidant power, and thiobarbituric acid reactive substances (TBARS) methods were used to determine antioxidant potential. To evaluate the essential oil’s antimicrobial activity, minimum inhibitory concentrations (MIC) in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were calculated. Hemolytic activity was determined in sheep red blood cells. Thirty-one compounds were identified via GC-MS analysis, representing 81.60% of the total essential oil. These compounds included: turmerone (27.97%), fokienol (13.47%), ledol (9.78%), and santalol (5.35%). The class of compounds identified was the oxygenated sesquiterpenes (62.52%). Antioxidant activity was confirmed via phosphomolybdenum complex formation and TBARS methods. Moderate antimicrobial activity and low hemolysis rates were displayed at concentrations of 250 and 500 μg/mL. |
| first_indexed | 2024-04-14T05:00:14Z |
| format | Article |
| id | doaj.art-ea57658f3051425ca6cc691ab2f53e42 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-14T05:00:14Z |
| publishDate | 2022-05-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-ea57658f3051425ca6cc691ab2f53e422022-12-22T02:11:00ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-05-015810.1590/s2175-97902022e19118Chemical composition and biological activity of Baccharis erioclada DC. essential oilVanessa Barbosa Bobekhttps://orcid.org/0000-0002-2836-2076Luiza Stolz CruzCamila Freitas de Oliveirahttps://orcid.org/0000-0002-8549-5182Fernando Cesar Martins BetimJuliane Nadal Dias Swiechhttps://orcid.org/0000-0002-5106-9767Daniela Gaspardo FolquittoCarmen Antonia Sanches ItoJane Manfron Budelhttps://orcid.org/0000-0003-1873-2253Sandra Maria Warumby ZaninJosiane de Fátima Padilha de PaulaObdúlio Gomes MiguelAbstract The chemically complex essential oils of Baccharis species are associated with several biological activities, such as antimicrobial and antiulcerous properties. However, few studies have investigated Baccharis erioclada DC. Therefore, in this study, we aimed to characterize the essential oil of B. erioclada and evaluate its antioxidant, antimicrobial, and hemolytic potential. The essential oil was extracted by hydrodistillation using a Clevenger apparatus and analyzed via gas chromatography-mass spectrometry (GC-MS). Phosphomolybdenum complex formation, reducing antioxidant power, and thiobarbituric acid reactive substances (TBARS) methods were used to determine antioxidant potential. To evaluate the essential oil’s antimicrobial activity, minimum inhibitory concentrations (MIC) in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were calculated. Hemolytic activity was determined in sheep red blood cells. Thirty-one compounds were identified via GC-MS analysis, representing 81.60% of the total essential oil. These compounds included: turmerone (27.97%), fokienol (13.47%), ledol (9.78%), and santalol (5.35%). The class of compounds identified was the oxygenated sesquiterpenes (62.52%). Antioxidant activity was confirmed via phosphomolybdenum complex formation and TBARS methods. Moderate antimicrobial activity and low hemolysis rates were displayed at concentrations of 250 and 500 μg/mL.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100571&lng=en&tlng=enVolatile oilAsteraceaeVassoura-lageana |
| spellingShingle | Vanessa Barbosa Bobek Luiza Stolz Cruz Camila Freitas de Oliveira Fernando Cesar Martins Betim Juliane Nadal Dias Swiech Daniela Gaspardo Folquitto Carmen Antonia Sanches Ito Jane Manfron Budel Sandra Maria Warumby Zanin Josiane de Fátima Padilha de Paula Obdúlio Gomes Miguel Chemical composition and biological activity of Baccharis erioclada DC. essential oil Brazilian Journal of Pharmaceutical Sciences Volatile oil Asteraceae Vassoura-lageana |
| title | Chemical composition and biological activity of Baccharis erioclada DC. essential oil |
| title_full | Chemical composition and biological activity of Baccharis erioclada DC. essential oil |
| title_fullStr | Chemical composition and biological activity of Baccharis erioclada DC. essential oil |
| title_full_unstemmed | Chemical composition and biological activity of Baccharis erioclada DC. essential oil |
| title_short | Chemical composition and biological activity of Baccharis erioclada DC. essential oil |
| title_sort | chemical composition and biological activity of baccharis erioclada dc essential oil |
| topic | Volatile oil Asteraceae Vassoura-lageana |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100571&lng=en&tlng=en |
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