Advances in the Knowledge about Kidney Decellularization and Repopulation
End-stage renal disease (ESRD) is characterized by the progressive deterioration of renal function that may compromise different tissues and organs. The major treatment indicated for patients with ESRD is kidney transplantation. However, the shortage of available organs, as well as the high rate of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fbioe.2017.00034/full |
| _version_ | 1818298175257051136 |
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| author | Afrânio Côgo Destefani Afrânio Côgo Destefani Afrânio Côgo Destefani Gabriela Modenesi Sirtoli Gabriela Modenesi Sirtoli Breno Valentim Nogueira Breno Valentim Nogueira Breno Valentim Nogueira |
| author_facet | Afrânio Côgo Destefani Afrânio Côgo Destefani Afrânio Côgo Destefani Gabriela Modenesi Sirtoli Gabriela Modenesi Sirtoli Breno Valentim Nogueira Breno Valentim Nogueira Breno Valentim Nogueira |
| author_sort | Afrânio Côgo Destefani |
| collection | DOAJ |
| description | End-stage renal disease (ESRD) is characterized by the progressive deterioration of renal function that may compromise different tissues and organs. The major treatment indicated for patients with ESRD is kidney transplantation. However, the shortage of available organs, as well as the high rate of organ rejection, supports the need for new therapies. Thus, the implementation of tissue bioengineering to organ regeneration has emerged as an alternative to traditional organ transplantation. Decellularization of organs with chemical, physical, and/or biological agents generates natural scaffolds, which can serve as basis for tissue reconstruction. The recellularization of these scaffolds with different cell sources, such as stem cells or adult differentiated cells, can provide an organ with functionality and no immune response after in vivo transplantation on the host. Several studies have focused on improving these techniques, but until now, there is no optimal decellularization method for the kidney available yet. Herein, an overview of the current literature for kidney decellularization and whole-organ recellularization is presented, addressing the pros and cons of the actual techniques already developed, the methods adopted to evaluate the efficacy of the procedures, and the challenges to be overcome in order to achieve an optimal protocol. |
| first_indexed | 2024-12-13T04:31:09Z |
| format | Article |
| id | doaj.art-ea57ad665d6a48dab24d162c6064524d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-13T04:31:09Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-ea57ad665d6a48dab24d162c6064524d2022-12-21T23:59:32ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852017-06-01510.3389/fbioe.2017.00034255314Advances in the Knowledge about Kidney Decellularization and RepopulationAfrânio Côgo Destefani0Afrânio Côgo Destefani1Afrânio Côgo Destefani2Gabriela Modenesi Sirtoli3Gabriela Modenesi Sirtoli4Breno Valentim Nogueira5Breno Valentim Nogueira6Breno Valentim Nogueira7Tissue Engineering Core—LUCCAR, Morphology, Federal University of Espírito Santo (UFES), Vitória, BrazilHealth Sciences Center, Federal University of Espírito Santo (UFES), Vitória, BrazilHealth Sciences Center, Postgraduate Program in Biotechnology/RENORBIO, Vitória, BrazilTissue Engineering Core—LUCCAR, Morphology, Federal University of Espírito Santo (UFES), Vitória, BrazilHealth Sciences Center, Federal University of Espírito Santo (UFES), Vitória, BrazilTissue Engineering Core—LUCCAR, Morphology, Federal University of Espírito Santo (UFES), Vitória, BrazilHealth Sciences Center, Federal University of Espírito Santo (UFES), Vitória, BrazilHealth Sciences Center, Postgraduate Program in Biotechnology/RENORBIO, Vitória, BrazilEnd-stage renal disease (ESRD) is characterized by the progressive deterioration of renal function that may compromise different tissues and organs. The major treatment indicated for patients with ESRD is kidney transplantation. However, the shortage of available organs, as well as the high rate of organ rejection, supports the need for new therapies. Thus, the implementation of tissue bioengineering to organ regeneration has emerged as an alternative to traditional organ transplantation. Decellularization of organs with chemical, physical, and/or biological agents generates natural scaffolds, which can serve as basis for tissue reconstruction. The recellularization of these scaffolds with different cell sources, such as stem cells or adult differentiated cells, can provide an organ with functionality and no immune response after in vivo transplantation on the host. Several studies have focused on improving these techniques, but until now, there is no optimal decellularization method for the kidney available yet. Herein, an overview of the current literature for kidney decellularization and whole-organ recellularization is presented, addressing the pros and cons of the actual techniques already developed, the methods adopted to evaluate the efficacy of the procedures, and the challenges to be overcome in order to achieve an optimal protocol.http://journal.frontiersin.org/article/10.3389/fbioe.2017.00034/fullkidney transplantationbioengineeringdecellularizationregenerative medicinestem cell |
| spellingShingle | Afrânio Côgo Destefani Afrânio Côgo Destefani Afrânio Côgo Destefani Gabriela Modenesi Sirtoli Gabriela Modenesi Sirtoli Breno Valentim Nogueira Breno Valentim Nogueira Breno Valentim Nogueira Advances in the Knowledge about Kidney Decellularization and Repopulation Frontiers in Bioengineering and Biotechnology kidney transplantation bioengineering decellularization regenerative medicine stem cell |
| title | Advances in the Knowledge about Kidney Decellularization and Repopulation |
| title_full | Advances in the Knowledge about Kidney Decellularization and Repopulation |
| title_fullStr | Advances in the Knowledge about Kidney Decellularization and Repopulation |
| title_full_unstemmed | Advances in the Knowledge about Kidney Decellularization and Repopulation |
| title_short | Advances in the Knowledge about Kidney Decellularization and Repopulation |
| title_sort | advances in the knowledge about kidney decellularization and repopulation |
| topic | kidney transplantation bioengineering decellularization regenerative medicine stem cell |
| url | http://journal.frontiersin.org/article/10.3389/fbioe.2017.00034/full |
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