The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1

The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1

Human apurinic/apyrimidinic (AP) endonuclease APE1 hydrolyzes phosphodiester bonds on the 5′ side of an AP-site, and some damaged nucleotides such as 1,N6-ethenoadenosine (εA), α-adenosine (αA), and 5,6-dihydrouridine (DHU). To investigate the mechanism behind the broad substrate specificity of APE1...

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Bibliographic Details
Main Authors: Anatoly A. Bulygin, Alexandra A. Kuznetsova, Yuri N. Vorobjev, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
base excision repair
AP endonuclease
conformational dynamics
active site plasticity
apurinic/apyrimidinic site
5,6-dihydrouridine
Online Access:https://www.mdpi.com/1420-3049/25/17/3940

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