The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China
BackgroundThe impact of weight loss and/or improved metabolic status on the risk of non-alcoholic fatty liver disease (NAFLD) has yet to be determined.MethodsA total of 35,322 participants without NAFLD were followed. NAFLD risk was compared between consistently metabolically healthy non-obese (MHNO...
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1239996/full |
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| author | Xin Huang Wenbin Ouyang Yang Hu Bei Tang Yongmei He Hao Wu Pingting Yang Lu Yin Qingqi Liu Kui Chen Jing Deng Xiaohui Li Ying Li |
| author_facet | Xin Huang Wenbin Ouyang Yang Hu Bei Tang Yongmei He Hao Wu Pingting Yang Lu Yin Qingqi Liu Kui Chen Jing Deng Xiaohui Li Ying Li |
| author_sort | Xin Huang |
| collection | DOAJ |
| description | BackgroundThe impact of weight loss and/or improved metabolic status on the risk of non-alcoholic fatty liver disease (NAFLD) has yet to be determined.MethodsA total of 35,322 participants without NAFLD were followed. NAFLD risk was compared between consistently metabolically healthy non-obese (MHNO) and non-MHNO who lost weight to become non-obese and/or improved their metabolic health, using Cox proportional hazards and logistic regression models.ResultsFollowing 148,186 person-years, 8,409 participants had onset NAFLD, with an incidence rate of 56.75 (95% CI: 55.57, 57.94) per 1,000 person-years. Metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), and metabolically unhealthy non-obese (MUNO) at baseline were associated with increased NAFLD risk, with hazard ratios of 4.48 (95%CI:4.24, 4.73), 8.85 (95%CI:7.95, 9.84), and 10.70 (95%CI:9.73, 11.78). Weight loss and/or metabolic status improvements could significantly reduce NAFLD risk by 79.46 to 41.46%. Specifically, after weight loss from MHO to MHNO, the reduction in NAFLD risk [OR decreased from 12.01 (95%CI:9.40, 15.35) to 4.14 (95%CI:3.08, 5.57)] was greater than that of the MUNO subgroup whose metabolic status improved to MHNO [OR decreased from 5.53 (95%CI:5.15, 5.94) to 2.71 (95%CI:2.50, 3.93)]. In the MUO subgroup, the group with the greatest risk reduction of NAFLD was the weight and metabolic state both improvement group [MUO to MHNO, OR decreased from 22.74 (95%CI:17.61, 29.37) to 4.67 (95%CI:3.05, 7.16)], followed by the weight loss only group [MUO to MUNO, OR decreased to 6.83 (95%CI:4.87, 9.57)], and finally the group with the least and insignificant risk reduction was the metabolic state improvement group [MUO to MHO, OR decreased to 13.38 (95%CI:9.17,19.53)]. NAFLD risk was negatively correlated with the duration of improvement (p < 0.001).ConclusionIndividuals with non-MHNO were more likely to develop NAFLD than those with consistent MHNO, but metabolic improvements and weight loss can alleviate the risk. Their NAFLD risk was negatively correlated with improvement duration. However, it remained higher than in individuals with consistent MHNO at an average follow-up of 4.2 years. |
| first_indexed | 2024-03-09T14:23:15Z |
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| publishDate | 2023-11-01 |
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| spelling | doaj.art-ea5c88cd8f854d74bbff3ff0f89ceaea2023-11-28T09:40:17ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12399961239996The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in ChinaXin Huang0Wenbin Ouyang1Yang Hu2Bei Tang3Yongmei He4Hao Wu5Pingting Yang6Lu Yin7Qingqi Liu8Kui Chen9Jing Deng10Xiaohui Li11Ying Li12Department of Epidemiology, Hunan Normal University School of Medicine, Changsha, ChinaDepartment of Epidemiology, Hunan Normal University School of Medicine, Changsha, ChinaDepartment of Epidemiology, Hunan Normal University School of Medicine, Changsha, ChinaDepartment of Epidemiology, Hunan Normal University School of Medicine, Changsha, ChinaDepartment of Health Management, Aerospace Center Hospital, Beijing, ChinaDepartment of Health Management, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Health Management, The Third Xiangya Hospital, Central South University, Changsha, ChinaMedical Research and Biometrics Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, DC, United StatesDepartment of Health Management, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Epidemiology, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Science, Central South University, Changsha, Hunan, ChinaDepartment of Health Management, The Third Xiangya Hospital, Central South University, Changsha, ChinaBackgroundThe impact of weight loss and/or improved metabolic status on the risk of non-alcoholic fatty liver disease (NAFLD) has yet to be determined.MethodsA total of 35,322 participants without NAFLD were followed. NAFLD risk was compared between consistently metabolically healthy non-obese (MHNO) and non-MHNO who lost weight to become non-obese and/or improved their metabolic health, using Cox proportional hazards and logistic regression models.ResultsFollowing 148,186 person-years, 8,409 participants had onset NAFLD, with an incidence rate of 56.75 (95% CI: 55.57, 57.94) per 1,000 person-years. Metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), and metabolically unhealthy non-obese (MUNO) at baseline were associated with increased NAFLD risk, with hazard ratios of 4.48 (95%CI:4.24, 4.73), 8.85 (95%CI:7.95, 9.84), and 10.70 (95%CI:9.73, 11.78). Weight loss and/or metabolic status improvements could significantly reduce NAFLD risk by 79.46 to 41.46%. Specifically, after weight loss from MHO to MHNO, the reduction in NAFLD risk [OR decreased from 12.01 (95%CI:9.40, 15.35) to 4.14 (95%CI:3.08, 5.57)] was greater than that of the MUNO subgroup whose metabolic status improved to MHNO [OR decreased from 5.53 (95%CI:5.15, 5.94) to 2.71 (95%CI:2.50, 3.93)]. In the MUO subgroup, the group with the greatest risk reduction of NAFLD was the weight and metabolic state both improvement group [MUO to MHNO, OR decreased from 22.74 (95%CI:17.61, 29.37) to 4.67 (95%CI:3.05, 7.16)], followed by the weight loss only group [MUO to MUNO, OR decreased to 6.83 (95%CI:4.87, 9.57)], and finally the group with the least and insignificant risk reduction was the metabolic state improvement group [MUO to MHO, OR decreased to 13.38 (95%CI:9.17,19.53)]. NAFLD risk was negatively correlated with the duration of improvement (p < 0.001).ConclusionIndividuals with non-MHNO were more likely to develop NAFLD than those with consistent MHNO, but metabolic improvements and weight loss can alleviate the risk. Their NAFLD risk was negatively correlated with improvement duration. However, it remained higher than in individuals with consistent MHNO at an average follow-up of 4.2 years.https://www.frontiersin.org/articles/10.3389/fnut.2023.1239996/fullobesitymetabolic healthNAFLDcohort studyloss weight |
| spellingShingle | Xin Huang Wenbin Ouyang Yang Hu Bei Tang Yongmei He Hao Wu Pingting Yang Lu Yin Qingqi Liu Kui Chen Jing Deng Xiaohui Li Ying Li The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China Frontiers in Nutrition obesity metabolic health NAFLD cohort study loss weight |
| title | The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China |
| title_full | The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China |
| title_fullStr | The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China |
| title_full_unstemmed | The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China |
| title_short | The effects of weight loss and improved metabolic health status on the risk of non-alcoholic fatty liver disease—results from a prospective cohort in China |
| title_sort | effects of weight loss and improved metabolic health status on the risk of non alcoholic fatty liver disease results from a prospective cohort in china |
| topic | obesity metabolic health NAFLD cohort study loss weight |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1239996/full |
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