HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress

HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress

The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has not only resulted in a dramatic decrease in the peripheral viral load but has also led to increased life expectancy of the infected individuals. Paradoxically, increased lifespan is accompanied with higher...

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Bibliographic Details
Main Authors: Annadurai Thangaraj, Ernest T. Chivero, Ashutosh Tripathi, Seema Singh, Fang Niu, Ming-Lei Guo, Prakash Pillai, Palsamy Periyasamy, Shilpa Buch
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
Mitochondria stress
SIRT3
HIV TAT
Microglial activation
Neuroinflammation
miRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172031048X

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