Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study
Abstract Background Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein...
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-017-0530-x |
| _version_ | 1818670833457954816 |
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| author | Tiina Vilmi-Kerälä Anneli Lauhio Taina Tervahartiala Outi Palomäki Jukka Uotila Timo Sorsa Ari Palomäki |
| author_facet | Tiina Vilmi-Kerälä Anneli Lauhio Taina Tervahartiala Outi Palomäki Jukka Uotila Timo Sorsa Ari Palomäki |
| author_sort | Tiina Vilmi-Kerälä |
| collection | DOAJ |
| description | Abstract Background Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery. We also investigated possible effects of obesity on the results. Methods We studied two cohorts—120 women with a history of GDM and 120 controls—on average 3.7 years after delivery. Serum concentrations of hsCRP were determined by immunonephelometric and immunoturbidimetric methods, MMP-8 by immunofluorometric assay, and MMP-9 and TIMP-1 by enzyme-linked immunosorbent assays. Pulse wave velocity (PWV) was determined using the foot-to-foot velocity method from carotid and femoral waveforms by using a SphygmoCor device. Arterial compliance was measured non-invasively by an HDI/PulseWave™CR-2000 arterial tonometer. All 240 women were also included in subgroup analyses to study the effect of obesity on the results. Multiple linear regression analyses were performed with adjustment for confounding factors. Results PWV after pregnancy complicated by GDM was significantly higher than after normal pregnancy, 6.44 ± 0.83 (SD) vs. 6.17 ± 0.74 m/s (p = 0.009). Previous GDM was also one of the significant determinants of PWV in multiple linear regression analyses. On the other hand, compliance indices of both large (p = 0.092) and small (p = 0.681) arteries did not differ between the study cohorts. Serum TIMP-1 levels were significantly increased after previous GDM (p = 0.020). However, no differences were found in the serum levels of MMP-8, MMP-9 or hsCRP. In subgroup analyses, there were significantly higher concentrations of hsCRP (p = 0.015) and higher PWV (p < 0.001) among obese women compared with non-obese ones. Conclusions PWV values were significantly higher after GDM compared with normoglycemic pregnancies and were associated with prolonged TIMP-1 upregulation. Cardiovascular risk factors were more common in participants with high BMI than in those with previous GDM. |
| first_indexed | 2024-12-17T07:14:23Z |
| format | Article |
| id | doaj.art-ea62876bb8b24fe89511cbda48141b7e |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-17T07:14:23Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ea62876bb8b24fe89511cbda48141b7e2022-12-21T21:58:56ZengBMCCardiovascular Diabetology1475-28402017-04-0116111010.1186/s12933-017-0530-xSubclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort studyTiina Vilmi-Kerälä0Anneli Lauhio1Taina Tervahartiala2Outi Palomäki3Jukka Uotila4Timo Sorsa5Ari Palomäki6School of Medicine, University of TampereDepartment of Infectious Diseases, Inflammation Center, Helsinki University HospitalDepartment of Oral and Maxillofacial Diseases, Helsinki University and University HospitalDepartment of Obstetrics and Gynecology, Tampere University HospitalSchool of Medicine, University of TampereDepartment of Oral and Maxillofacial Diseases, Helsinki University and University HospitalSchool of Medicine, University of TampereAbstract Background Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery. We also investigated possible effects of obesity on the results. Methods We studied two cohorts—120 women with a history of GDM and 120 controls—on average 3.7 years after delivery. Serum concentrations of hsCRP were determined by immunonephelometric and immunoturbidimetric methods, MMP-8 by immunofluorometric assay, and MMP-9 and TIMP-1 by enzyme-linked immunosorbent assays. Pulse wave velocity (PWV) was determined using the foot-to-foot velocity method from carotid and femoral waveforms by using a SphygmoCor device. Arterial compliance was measured non-invasively by an HDI/PulseWave™CR-2000 arterial tonometer. All 240 women were also included in subgroup analyses to study the effect of obesity on the results. Multiple linear regression analyses were performed with adjustment for confounding factors. Results PWV after pregnancy complicated by GDM was significantly higher than after normal pregnancy, 6.44 ± 0.83 (SD) vs. 6.17 ± 0.74 m/s (p = 0.009). Previous GDM was also one of the significant determinants of PWV in multiple linear regression analyses. On the other hand, compliance indices of both large (p = 0.092) and small (p = 0.681) arteries did not differ between the study cohorts. Serum TIMP-1 levels were significantly increased after previous GDM (p = 0.020). However, no differences were found in the serum levels of MMP-8, MMP-9 or hsCRP. In subgroup analyses, there were significantly higher concentrations of hsCRP (p = 0.015) and higher PWV (p < 0.001) among obese women compared with non-obese ones. Conclusions PWV values were significantly higher after GDM compared with normoglycemic pregnancies and were associated with prolonged TIMP-1 upregulation. Cardiovascular risk factors were more common in participants with high BMI than in those with previous GDM.http://link.springer.com/article/10.1186/s12933-017-0530-xArterial complianceGestational diabetes mellitusHigh-sensitivity C-reactive proteinMatrix metalloproteinase-8Matrix metalloproteinase-9Pulse wave velocity |
| spellingShingle | Tiina Vilmi-Kerälä Anneli Lauhio Taina Tervahartiala Outi Palomäki Jukka Uotila Timo Sorsa Ari Palomäki Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study Cardiovascular Diabetology Arterial compliance Gestational diabetes mellitus High-sensitivity C-reactive protein Matrix metalloproteinase-8 Matrix metalloproteinase-9 Pulse wave velocity |
| title | Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study |
| title_full | Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study |
| title_fullStr | Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study |
| title_full_unstemmed | Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study |
| title_short | Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study |
| title_sort | subclinical inflammation associated with prolonged timp 1 upregulation and arterial stiffness after gestational diabetes mellitus a hospital based cohort study |
| topic | Arterial compliance Gestational diabetes mellitus High-sensitivity C-reactive protein Matrix metalloproteinase-8 Matrix metalloproteinase-9 Pulse wave velocity |
| url | http://link.springer.com/article/10.1186/s12933-017-0530-x |
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