Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study
AbstractBackground Anxiety and depression are common comorbidities in idiopathic pulmonary fibrosis (IPF) that impair health-related quality of life. However, there is a lack of studies focusing on the mental disorder of IPF after antifibrotic treatment and their related predictive factors.Methods P...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2323097 |
| _version_ | 1797220369455644672 |
|---|---|
| author | Xing He Jiaqi Ji Zongmin Pei Zeli Luo Siyu Fang Xiaoqin Liu Yan Lei Haiying Yan Lu Guo |
| author_facet | Xing He Jiaqi Ji Zongmin Pei Zeli Luo Siyu Fang Xiaoqin Liu Yan Lei Haiying Yan Lu Guo |
| author_sort | Xing He |
| collection | DOAJ |
| description | AbstractBackground Anxiety and depression are common comorbidities in idiopathic pulmonary fibrosis (IPF) that impair health-related quality of life. However, there is a lack of studies focusing on the mental disorder of IPF after antifibrotic treatment and their related predictive factors.Methods Patients with an initial diagnosis of IPF were enrolled. Data on demographics, lung function, Generalized Anxiety Disorder-7 (GAD-7) Scale, Patient Health Questionnaire 9 (PHQ-9), Patient Health Questionnaire-15 (PHQ-15), and St. George's Respiratory Questionnaire total score(SGRQ-T) were collected. Changes in anxiety, depression, somatic symptoms, and quality of life scores before and after nintedanib treatment were compared, and the related predictive factors were analyzed.Results A total of 56 patients with a first diagnosis of IPF were enrolled, with 42 and 35 patients suffering from anxiety and depression, respectively. The GAD-7, PHQ-9, PHQ-15, and SGRQ scores were higher in the anxiety and depression groups. SGRQ total score (SGRQ-T) [OR = 1.075, 95%CI= (1.011, 1.142)] was an independent predictor of IPF combined with anxiety (p < 0.05); SGRQ-T [OR = 1.080, 95%CI= (1.001, 1.167)] was also an independent predictor of IPF combined with depression (p < 0.05). After treatment, GAD-7, PHQ-9, PHQ-15, and SGRQ scores decreased (p < 0.05). ΔSGRQ-T significantly affected ΔGAD-7 (β = 0.376, p = 0.009) and ΔPHQ-9 (β = 0.329, p = 0.022).Conclusion Anxiety and depression in IPF patients are closely related to somatic symptoms, pulmonary function, and quality of life. The SGRQ-T score is of great value for assessing anxiety and depression in patients with IPF. Short-term treatment with nintedanib antifibrotic therapy can alleviate anxiety and depression in IPF patients. |
| first_indexed | 2024-04-24T12:48:27Z |
| format | Article |
| id | doaj.art-ea62c8c7a1344cc8bcee2e471102ef5a |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-24T12:48:27Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-ea62c8c7a1344cc8bcee2e471102ef5a2024-04-06T16:05:56ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2323097Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational studyXing He0Jiaqi Ji1Zongmin Pei2Zeli Luo3Siyu Fang4Xiaoqin Liu5Yan Lei6Haiying Yan7Lu Guo8Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, ChinaDepartment of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, ChinaDepartment of Psychosomatic Medicine, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, ChinaDepartment of Critical Care Medicine, Wenjiang District People's Hospital, Chengdu, Sichuan Province, ChinaDepartment of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, ChinaDepartment of Pulmonary and Critical Care Medicine, Cheng Du Qing Cheng Mt. Hospital, Chongzhou City, Chengdu, Sichuan Province, ChinaDepartment of Pulmonary and Critical Care Medicine, Cheng Du Qing Cheng Mt. Hospital, Chongzhou City, Chengdu, Sichuan Province, ChinaDepartment of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, ChinaDepartment of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, ChinaAbstractBackground Anxiety and depression are common comorbidities in idiopathic pulmonary fibrosis (IPF) that impair health-related quality of life. However, there is a lack of studies focusing on the mental disorder of IPF after antifibrotic treatment and their related predictive factors.Methods Patients with an initial diagnosis of IPF were enrolled. Data on demographics, lung function, Generalized Anxiety Disorder-7 (GAD-7) Scale, Patient Health Questionnaire 9 (PHQ-9), Patient Health Questionnaire-15 (PHQ-15), and St. George's Respiratory Questionnaire total score(SGRQ-T) were collected. Changes in anxiety, depression, somatic symptoms, and quality of life scores before and after nintedanib treatment were compared, and the related predictive factors were analyzed.Results A total of 56 patients with a first diagnosis of IPF were enrolled, with 42 and 35 patients suffering from anxiety and depression, respectively. The GAD-7, PHQ-9, PHQ-15, and SGRQ scores were higher in the anxiety and depression groups. SGRQ total score (SGRQ-T) [OR = 1.075, 95%CI= (1.011, 1.142)] was an independent predictor of IPF combined with anxiety (p < 0.05); SGRQ-T [OR = 1.080, 95%CI= (1.001, 1.167)] was also an independent predictor of IPF combined with depression (p < 0.05). After treatment, GAD-7, PHQ-9, PHQ-15, and SGRQ scores decreased (p < 0.05). ΔSGRQ-T significantly affected ΔGAD-7 (β = 0.376, p = 0.009) and ΔPHQ-9 (β = 0.329, p = 0.022).Conclusion Anxiety and depression in IPF patients are closely related to somatic symptoms, pulmonary function, and quality of life. The SGRQ-T score is of great value for assessing anxiety and depression in patients with IPF. Short-term treatment with nintedanib antifibrotic therapy can alleviate anxiety and depression in IPF patients.https://www.tandfonline.com/doi/10.1080/07853890.2024.2323097Idiopathic pulmonary fibrosisanxietydepressionquality of lifeantifibrotic therapy |
| spellingShingle | Xing He Jiaqi Ji Zongmin Pei Zeli Luo Siyu Fang Xiaoqin Liu Yan Lei Haiying Yan Lu Guo Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study Annals of Medicine Idiopathic pulmonary fibrosis anxiety depression quality of life antifibrotic therapy |
| title | Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study |
| title_full | Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study |
| title_fullStr | Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study |
| title_full_unstemmed | Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study |
| title_short | Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study |
| title_sort | anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment an observational study |
| topic | Idiopathic pulmonary fibrosis anxiety depression quality of life antifibrotic therapy |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2323097 |
| work_keys_str_mv | AT xinghe anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT jiaqiji anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT zongminpei anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT zeliluo anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT siyufang anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT xiaoqinliu anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT yanlei anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT haiyingyan anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy AT luguo anxietyanddepressionstatusinpatientswithidiopathicpulmonaryfibrosisandoutcomesofnintedanibtreatmentanobservationalstudy |