Retained introns in long RNA-seq reads are not reliably detected in sample-matched short reads

Retained introns in long RNA-seq reads are not reliably detected in sample-matched short reads

Abstract Background There is growing interest in retained introns in a variety of disease contexts including cancer and aging. Many software tools have been developed to detect retained introns from short RNA-seq reads, but reliable detection is complicated by overlapping genes and transcripts as we...

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Bibliographic Details
Main Authors: Julianne K. David, Sean K. Maden, Mary A. Wood, Reid F. Thompson, Abhinav Nellore
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Genome Biology
Subjects:
RNA-seq
Splicing
Intron retention
Online Access:https://doi.org/10.1186/s13059-022-02789-6

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