Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019
ABSTRACT: Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe. Methods: We conducted a retrospective study of paras...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222003605 |
| _version_ | 1798032185122357248 |
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| author | Hedvig Glans Leif Dotevall Gert Van der Auwera Aldert Bart Johannes Blum Pierre Buffet Romain Guery Jean-Pierre Gangneux Saskia van Henten Gundel Harms Stefania Varani Florence Robert-Gangneux Robert Rongisch Björn Andersson Maria Bradley |
| author_facet | Hedvig Glans Leif Dotevall Gert Van der Auwera Aldert Bart Johannes Blum Pierre Buffet Romain Guery Jean-Pierre Gangneux Saskia van Henten Gundel Harms Stefania Varani Florence Robert-Gangneux Robert Rongisch Björn Andersson Maria Bradley |
| author_sort | Hedvig Glans |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe. Methods: We conducted a retrospective study of parasitological confirmed CL cases caused by L. major and L. tropica during 2013-2019 in Europe. Data were collected from medical records and databases within the LeishMan network. Results: Of 206 included cases of CL, 75 were identified as L. major and 131 as L. tropica. Of patients with L. tropica infection, 80% were migrants, whereas 53% of patients with L. major infection had been visiting friends and relatives. Among patients with L. tropica, 48% were younger than 15 years. Pentavalent antimony cured 73% (L. major) and 78% (L. tropica) of patients. The cure rate for intralesional administration was 86% and 67% for systemic, on L. tropica. Liposomal amphotericin B had a cure rate of 44-63%. Conclusion: L. major infections were mostly found in individuals visiting friends and relatives, whereas L. tropica were mainly identified in migrants. No patients with L. major relapsed. Pentavalent antimony, liposomal amphotericin B, and cryotherapy had cure rates in accordance with previous studies. |
| first_indexed | 2024-04-11T20:08:40Z |
| format | Article |
| id | doaj.art-ea63c50095ed40cb8578cb36124e4f57 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T20:08:40Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-ea63c50095ed40cb8578cb36124e4f572022-12-22T04:05:14ZengElsevierInternational Journal of Infectious Diseases1201-97122022-09-01122375381Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019Hedvig Glans0Leif Dotevall1Gert Van der Auwera2Aldert Bart3Johannes Blum4Pierre Buffet5Romain Guery6Jean-Pierre Gangneux7Saskia van Henten8Gundel Harms9Stefania Varani10Florence Robert-Gangneux11Robert Rongisch12Björn Andersson13Maria Bradley14Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Corresponding author: Hedvig Glans, Division of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, 17176 Stockholm, Sweden.Department of Communicable Disease Control Region, Västra Götaland, Gothenburg, SwedenInstitute of Tropical Medicine, Antwerp, BelgiumDepartment of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The NetherlandsUniversity of Basel, Petersplatz 1, Postfach 4001, Basel, Switzerland; Swiss Tropical and Public Health Institute, Basel, SwitzerlandUniversité Paris Cité, Biologie Intégrée du Globule Rouge, UMR_S1134, INSERM, F-75015, Paris, FranceDepartment of Internal Medicine and Infectious Diseases, Hôpital du Confluent, Nantes, FranceUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, 2 rue du Pr Léon Bernard, 35000 Rennes, FranceInstitute of Tropical Medicine, Antwerp, BelgiumInstitute of Tropical Medicine and International Health, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität, and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, ItalyUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, 2 rue du Pr Léon Bernard, 35000 Rennes, FranceDepartment of Dermatology and Venereology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, GermanyDepartment of Cell & Molecular Biology, Karolinska Institutet, Stockholm, SwedenDivision of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Stockholm, SwedenABSTRACT: Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe. Methods: We conducted a retrospective study of parasitological confirmed CL cases caused by L. major and L. tropica during 2013-2019 in Europe. Data were collected from medical records and databases within the LeishMan network. Results: Of 206 included cases of CL, 75 were identified as L. major and 131 as L. tropica. Of patients with L. tropica infection, 80% were migrants, whereas 53% of patients with L. major infection had been visiting friends and relatives. Among patients with L. tropica, 48% were younger than 15 years. Pentavalent antimony cured 73% (L. major) and 78% (L. tropica) of patients. The cure rate for intralesional administration was 86% and 67% for systemic, on L. tropica. Liposomal amphotericin B had a cure rate of 44-63%. Conclusion: L. major infections were mostly found in individuals visiting friends and relatives, whereas L. tropica were mainly identified in migrants. No patients with L. major relapsed. Pentavalent antimony, liposomal amphotericin B, and cryotherapy had cure rates in accordance with previous studies.http://www.sciencedirect.com/science/article/pii/S1201971222003605Cutaneous leishmaniasisLeishmania majorLeishmania tropicaTreatmentOutcome |
| spellingShingle | Hedvig Glans Leif Dotevall Gert Van der Auwera Aldert Bart Johannes Blum Pierre Buffet Romain Guery Jean-Pierre Gangneux Saskia van Henten Gundel Harms Stefania Varani Florence Robert-Gangneux Robert Rongisch Björn Andersson Maria Bradley Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019 International Journal of Infectious Diseases Cutaneous leishmaniasis Leishmania major Leishmania tropica Treatment Outcome |
| title | Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019 |
| title_full | Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019 |
| title_fullStr | Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019 |
| title_full_unstemmed | Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019 |
| title_short | Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019 |
| title_sort | treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with leishmania major and leishmania tropica a retrospective study in european centers 2013 to 2019 |
| topic | Cutaneous leishmaniasis Leishmania major Leishmania tropica Treatment Outcome |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222003605 |
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