<i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females
Background: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (<i>AMPD1</i>) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown....
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MDPI AG
2020-05-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/5/558 |
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| author | Agata Leońska-Duniec Ewelina Maculewicz Kinga Humińska-Lisowska Agnieszka Maciejewska-Skrendo Katarzyna Leźnicka Paweł Cięszczyk Marek Sawczuk Grzegorz Trybek Michal Wilk Weronika Lepionka Krzysztof Ficek |
| author_facet | Agata Leońska-Duniec Ewelina Maculewicz Kinga Humińska-Lisowska Agnieszka Maciejewska-Skrendo Katarzyna Leźnicka Paweł Cięszczyk Marek Sawczuk Grzegorz Trybek Michal Wilk Weronika Lepionka Krzysztof Ficek |
| author_sort | Agata Leońska-Duniec |
| collection | DOAJ |
| description | Background: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (<i>AMPD1</i>) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown. The aim of the study was to determine if the C34T polymorphism influences the effects of an exercise training. Methods: This study examines a group of one hundred and sixty-eight, young, non-obese Caucasian women in Poland who took part in a 12-week aerobic training program to determine the impact of allele and genotype distribution on training outcomes. Results: A two-way analysis of variance ANOVA was conducted assuming a dominant model by pooling rare homozygotes and heterozygotes (TT + CT, <i>n</i> = 79) and comparing against common homozygotes (CC, <i>n</i> = 89). Our results showed that the <i>AMPD1</i> C34T polymorphism was not related with selected parameters in study group. After completing the 12-week training program, a wide array of parameters (body mass, body mass index, fat mass, free fat mass, total body water) were significantly changed in the study participants with the exception of <i>AMPD1</i> genotypes, among whom no significant changes were observed. Conclusions: The results did not confirm that harboring the rs 17602729 T allele influences the effects of the training program. |
| first_indexed | 2024-03-10T19:47:11Z |
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| id | doaj.art-ea6642fe9261483ca2e081bbea7e1c54 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T19:47:11Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ea6642fe9261483ca2e081bbea7e1c542023-11-20T00:43:50ZengMDPI AGGenes2073-44252020-05-0111555810.3390/genes11050558<i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian FemalesAgata Leońska-Duniec0Ewelina Maculewicz1Kinga Humińska-Lisowska2Agnieszka Maciejewska-Skrendo3Katarzyna Leźnicka4Paweł Cięszczyk5Marek Sawczuk6Grzegorz Trybek7Michal Wilk8Weronika Lepionka9Krzysztof Ficek10Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandDepartment of Biomedical Sciences, Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00968 Warsaw, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, PolandDepartment of Oral Surgery, Pomeranian Medical University, 72 Powstanców Wlkp. St., 70-111 Szczecin, PolandInstitute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40065 Katowice, PolandEUAfME Drug Safety Unit (DSU) Regional Platform, Pfizer Poland, 02092 Warsaw, PolandInstitute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40065 Katowice, PolandBackground: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (<i>AMPD1</i>) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown. The aim of the study was to determine if the C34T polymorphism influences the effects of an exercise training. Methods: This study examines a group of one hundred and sixty-eight, young, non-obese Caucasian women in Poland who took part in a 12-week aerobic training program to determine the impact of allele and genotype distribution on training outcomes. Results: A two-way analysis of variance ANOVA was conducted assuming a dominant model by pooling rare homozygotes and heterozygotes (TT + CT, <i>n</i> = 79) and comparing against common homozygotes (CC, <i>n</i> = 89). Our results showed that the <i>AMPD1</i> C34T polymorphism was not related with selected parameters in study group. After completing the 12-week training program, a wide array of parameters (body mass, body mass index, fat mass, free fat mass, total body water) were significantly changed in the study participants with the exception of <i>AMPD1</i> genotypes, among whom no significant changes were observed. Conclusions: The results did not confirm that harboring the rs 17602729 T allele influences the effects of the training program.https://www.mdpi.com/2073-4425/11/5/558<i>AMPD1</i> geneC34TC34T polymorphismsport geneticsphysical activitytraining |
| spellingShingle | Agata Leońska-Duniec Ewelina Maculewicz Kinga Humińska-Lisowska Agnieszka Maciejewska-Skrendo Katarzyna Leźnicka Paweł Cięszczyk Marek Sawczuk Grzegorz Trybek Michal Wilk Weronika Lepionka Krzysztof Ficek <i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females Genes <i>AMPD1</i> gene C34T C34T polymorphism sport genetics physical activity training |
| title | <i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females |
| title_full | <i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females |
| title_fullStr | <i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females |
| title_full_unstemmed | <i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females |
| title_short | <i>AMPD1</i> C34T Polymorphism (rs17602729) Is Not Associated with Post-Exercise Changes of Body Weight, Body Composition, and Biochemical Parameters in Caucasian Females |
| title_sort | i ampd1 i c34t polymorphism rs17602729 is not associated with post exercise changes of body weight body composition and biochemical parameters in caucasian females |
| topic | <i>AMPD1</i> gene C34T C34T polymorphism sport genetics physical activity training |
| url | https://www.mdpi.com/2073-4425/11/5/558 |
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