Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy
AbstractObjective To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field.Methods Hybrid nanoparticles consisting of palladium-core...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2299480 |
| _version_ | 1797361830093389824 |
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| author | Rogier van Oossanen Alexandra Maier Jérémy Godart Jean-Philippe Pignol Antonia G. Denkova Gerard C. van Rhoon Kristina Djanashvili |
| author_facet | Rogier van Oossanen Alexandra Maier Jérémy Godart Jean-Philippe Pignol Antonia G. Denkova Gerard C. van Rhoon Kristina Djanashvili |
| author_sort | Rogier van Oossanen |
| collection | DOAJ |
| description | AbstractObjective To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field.Methods Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness, were suspended in water and their SLPs were measured at varying magnetic fields (12–26 mT peak) and frequencies (50–730 kHz) with a commercial alternating magnetic field generator (magneTherm™ Digital, nanoTherics Ltd.).Results Validation of the heating device used in this study with commercial HyperMag-C nanoparticles showed a small deviation (±4%) over a period of 1 year, confirming the reliability of the method. The integration of dual thermometers, one in the center and one at the bottom of the sample vial, allowed monitoring of homogeneity of the sample suspensions. SLPs measurements on a series of nanoparticles of increasing sizes showed the highest heating for the diameter of 21 nm (SLP = 225 W/g) at the applied frequencies of 346 and 730 kHz. No heating was observed for the nanoparticles with the size <14 nm, confirming the importance of the size-parameter. The heating ability of the best performing Pd/Fe-oxide-21 was calculated to be sufficient to ablate tumors with a radius ±4 and 12 mm using 10 and 1 mg/mL nanoparticle concentration, respectively.Conclusions Nanoparticles consisting of non-magnetic palladium-core and magnetic iron oxide shell are suitable for magnetic hyperthermia/thermal ablation under clinically safe conditions of 346 kHz and 19.1 mT, with minimal eddy current effects in combination with maximum SLP. |
| first_indexed | 2024-03-08T15:59:59Z |
| format | Article |
| id | doaj.art-ea665f96f5f64a9690ef32b2bb5cad07 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T15:59:59Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-ea665f96f5f64a9690ef32b2bb5cad072024-01-08T11:56:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2023.2299480Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapyRogier van Oossanen0Alexandra Maier1Jérémy Godart2Jean-Philippe Pignol3Antonia G. Denkova4Gerard C. van Rhoon5Kristina Djanashvili6Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The NetherlandsDepartment of Biotechnology, Delft University of Technology, Delft, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The NetherlandsDepartment of Radiation Science and Technology, Delft University of Technology, Delft, The NetherlandsDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The NetherlandsDepartment of Biotechnology, Delft University of Technology, Delft, The NetherlandsAbstractObjective To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field.Methods Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness, were suspended in water and their SLPs were measured at varying magnetic fields (12–26 mT peak) and frequencies (50–730 kHz) with a commercial alternating magnetic field generator (magneTherm™ Digital, nanoTherics Ltd.).Results Validation of the heating device used in this study with commercial HyperMag-C nanoparticles showed a small deviation (±4%) over a period of 1 year, confirming the reliability of the method. The integration of dual thermometers, one in the center and one at the bottom of the sample vial, allowed monitoring of homogeneity of the sample suspensions. SLPs measurements on a series of nanoparticles of increasing sizes showed the highest heating for the diameter of 21 nm (SLP = 225 W/g) at the applied frequencies of 346 and 730 kHz. No heating was observed for the nanoparticles with the size <14 nm, confirming the importance of the size-parameter. The heating ability of the best performing Pd/Fe-oxide-21 was calculated to be sufficient to ablate tumors with a radius ±4 and 12 mm using 10 and 1 mg/mL nanoparticle concentration, respectively.Conclusions Nanoparticles consisting of non-magnetic palladium-core and magnetic iron oxide shell are suitable for magnetic hyperthermia/thermal ablation under clinically safe conditions of 346 kHz and 19.1 mT, with minimal eddy current effects in combination with maximum SLP.https://www.tandfonline.com/doi/10.1080/02656736.2023.2299480Palladium iron/oxide nanoparticlesmagnetic hyperthermiathermal ablationthermo-brachytherapybreast cancer |
| spellingShingle | Rogier van Oossanen Alexandra Maier Jérémy Godart Jean-Philippe Pignol Antonia G. Denkova Gerard C. van Rhoon Kristina Djanashvili Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy International Journal of Hyperthermia Palladium iron/oxide nanoparticles magnetic hyperthermia thermal ablation thermo-brachytherapy breast cancer |
| title | Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy |
| title_full | Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy |
| title_fullStr | Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy |
| title_full_unstemmed | Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy |
| title_short | Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy |
| title_sort | magnetic hybrid pd fe oxide nanoparticles meet the demands for ablative thermo brachytherapy |
| topic | Palladium iron/oxide nanoparticles magnetic hyperthermia thermal ablation thermo-brachytherapy breast cancer |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2299480 |
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