The Prostaglandin E2 Pathway and Breast Cancer Stem Cells: Evidence of Increased Signaling and Potential Targeting

The Prostaglandin E2 Pathway and Breast Cancer Stem Cells: Evidence of Increased Signaling and Potential Targeting

Culprits of cancer development, metastasis, and drug resistance, cancer stem cells (CSCs) are characterized by specific markers, active developmental signaling pathways, metabolic plasticity, increased motility, invasiveness, and epithelial-mesenchymal transition. In breast cancer, these cells are o...

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Bibliographic Details
Main Authors: Olivia L. Walker, Margaret L. Dahn, Melanie R. Power Coombs, Paola Marcato
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
prostaglandin E2
breast cancer
cancer stem cells
aldehyde dehydrogenase
CD44+/CD24-
EP receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.791696/full

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