Activation of Polyamine Catabolism by N<sup>1</sup>,N<sup>11</sup>-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype

Activation of Polyamine Catabolism by N<sup>1</sup>,N<sup>11</sup>-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype

Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification within the local microenvironment. In particular, cancer cells exhibit elevated levels of biogenic polyamines. Inhibitors of polyamine biosynt...

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Bibliographic Details
Main Authors: Olga N. Ivanova, Anastasiya V. Snezhkina, George S. Krasnov, Vladimir T. Valuev-Elliston, Olga A. Khomich, Alexey R. Khomutov, Tuomo A. Keinanen, Leena Alhonen, Birke Bartosch, Anna V. Kudryavtseva, Sergey N. Kochetkov, Alexander V. Ivanov
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
polyamines
HepaRG
polyamine catabolism
dedifferentiation
EMT
spermidine
polyamine analogues
NextSeq
hepatocytes
Online Access:https://www.mdpi.com/2073-4409/7/12/275

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