Solving the health disparity of eczema assessment: A role for skin tape soluble protein?
Background: The assessment of erythema in patients with atopic dermatitis (AD) is based on clinical examination. The difficulty of perceiving erythema in Black patients with AD has led to underestimation of AD severity in these patients. Objective: In this study, we analyzed the concentration of ski...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829323001054 |
| _version_ | 1797317088932528128 |
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| author | Kittipos Visitsunthorn, MD Sanmeet Atwal, BS Elvira Lopez, BA Peck Y. Ong, MD |
| author_facet | Kittipos Visitsunthorn, MD Sanmeet Atwal, BS Elvira Lopez, BA Peck Y. Ong, MD |
| author_sort | Kittipos Visitsunthorn, MD |
| collection | DOAJ |
| description | Background: The assessment of erythema in patients with atopic dermatitis (AD) is based on clinical examination. The difficulty of perceiving erythema in Black patients with AD has led to underestimation of AD severity in these patients. Objective: In this study, we analyzed the concentration of skin tape soluble protein of AD lesions against common AD clinical signs. Method: A total of 50 children with AD were included. Skin tape total soluble protein was extracted from AD lesions and analyzed against validated AD clinical signs, including erythema, excoriation, edema, oozing, and lichenification. Results: Concentration of skin tape soluble protein is positively correlated with acute signs of AD, especially erythema. Conclusion: Determination of concentration of skin tape protein is a potential tool for grading erythema of AD lesions, and it may have an application in improving the health disparity of assessment of eczema severity in Black patients with AD. |
| first_indexed | 2024-03-08T03:29:50Z |
| format | Article |
| id | doaj.art-ea687ef6ef0a4ccd9016f454c15cf56d |
| institution | Directory Open Access Journal |
| issn | 2772-8293 |
| language | English |
| last_indexed | 2024-03-08T03:29:50Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj.art-ea687ef6ef0a4ccd9016f454c15cf56d2024-02-11T05:12:59ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932024-02-0131100180Solving the health disparity of eczema assessment: A role for skin tape soluble protein?Kittipos Visitsunthorn, MD0Sanmeet Atwal, BS1Elvira Lopez, BA2Peck Y. Ong, MD3Pediatric Residency Program and Children's Hospital Los Angeles, Los Angeles, CalifKeck School of Medicine, University of Southern California Los Angeles, Los Angeles, CalifDivision of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los Angeles, CalifKeck School of Medicine, University of Southern California Los Angeles, Los Angeles, Calif; Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los Angeles, Calif; Corresponding author: Peck Y. Ong, MD, Division of Clinical Immunology and Allergy, Children’s Hospital Los Angeles, 4650, Sunset Blvd, MS 75, Los Angeles, CA 90027.Background: The assessment of erythema in patients with atopic dermatitis (AD) is based on clinical examination. The difficulty of perceiving erythema in Black patients with AD has led to underestimation of AD severity in these patients. Objective: In this study, we analyzed the concentration of skin tape soluble protein of AD lesions against common AD clinical signs. Method: A total of 50 children with AD were included. Skin tape total soluble protein was extracted from AD lesions and analyzed against validated AD clinical signs, including erythema, excoriation, edema, oozing, and lichenification. Results: Concentration of skin tape soluble protein is positively correlated with acute signs of AD, especially erythema. Conclusion: Determination of concentration of skin tape protein is a potential tool for grading erythema of AD lesions, and it may have an application in improving the health disparity of assessment of eczema severity in Black patients with AD.http://www.sciencedirect.com/science/article/pii/S2772829323001054Atopic dermatitiserythemaracial disparitystrip skin tapestotal protein |
| spellingShingle | Kittipos Visitsunthorn, MD Sanmeet Atwal, BS Elvira Lopez, BA Peck Y. Ong, MD Solving the health disparity of eczema assessment: A role for skin tape soluble protein? Journal of Allergy and Clinical Immunology: Global Atopic dermatitis erythema racial disparity strip skin tapes total protein |
| title | Solving the health disparity of eczema assessment: A role for skin tape soluble protein? |
| title_full | Solving the health disparity of eczema assessment: A role for skin tape soluble protein? |
| title_fullStr | Solving the health disparity of eczema assessment: A role for skin tape soluble protein? |
| title_full_unstemmed | Solving the health disparity of eczema assessment: A role for skin tape soluble protein? |
| title_short | Solving the health disparity of eczema assessment: A role for skin tape soluble protein? |
| title_sort | solving the health disparity of eczema assessment a role for skin tape soluble protein |
| topic | Atopic dermatitis erythema racial disparity strip skin tapes total protein |
| url | http://www.sciencedirect.com/science/article/pii/S2772829323001054 |
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