Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults
Abstract Background Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatt...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | http://link.springer.com/article/10.1186/s12944-017-0531-5 |
| _version_ | 1819274520714805248 |
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| author | Xiaoya Zheng Lilin Gong Rong Luo Hua Chen Bin Peng Wei Ren Yonghong Wang |
| author_facet | Xiaoya Zheng Lilin Gong Rong Luo Hua Chen Bin Peng Wei Ren Yonghong Wang |
| author_sort | Xiaoya Zheng |
| collection | DOAJ |
| description | Abstract Background Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects. Methods Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. The data included completed anthropometry and blood biochemical indicators and the results of abdominal ultrasound. The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines for the diagnosis and treatment of nonalcoholic fatty liver disease in 2008. Results In total, 95,924 subjects were analyzed in this study. The prevalence rate of lean-NAFLD was 8.16%, among which 7.58% had mild steatosis, and 0.58% had moderate and severe steatosis. The prevalence of fatty liver was increased progressively with SUA. Among which the prevalence of mild fatty liver from Q1 to Q4 were 10.33%, 18.39%, 23.11% and 25.93%; the prevalence of moderate and severe fatty liver from Q1 to Q4 were 1.06%, 2.82%, 5.05% and 7.27%. Lean-subjects with hyperuricemia had an OR of 1.718 (95% CI 1.622–1.820) to have NAFLD, after adjusted for other metabolic disorders. The area under curve (AUC) for detecting mild fatty liver based on SUA was 0.70; and the AUC for detecting moderate and severe fatty liver based on SUA was 0.78. Conclusions Our data showed positive associations between elevated SUA levels and lean-NAFLD risk in the inland Chinese adults, independent of other metabolic factors. Our study also suggests that SUA could be considered as a simple and non-invasive method to follow up patients with lean-NAFLD. |
| first_indexed | 2024-12-23T23:09:44Z |
| format | Article |
| id | doaj.art-ea68bfa9c01b4deaa63ad5570c0a3760 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-23T23:09:44Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-ea68bfa9c01b4deaa63ad5570c0a37602022-12-21T17:26:41ZengBMCLipids in Health and Disease1476-511X2017-10-011611710.1186/s12944-017-0531-5Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adultsXiaoya Zheng0Lilin Gong1Rong Luo2Hua Chen3Bin Peng4Wei Ren5Yonghong Wang6Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, the First Affiliated Hospital of Chongqing Medical UniversityThe Public Health Center, the First Affiliated Hospital of Chongqing Medical UniversityDepartment of Statistics, Chongqing Medical UniversityDepartment of Statistics, Chongqing Medical UniversityDepartment of Endocrinology, the First Affiliated Hospital of Chongqing Medical UniversityThe Public Health Center, the First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects. Methods Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. The data included completed anthropometry and blood biochemical indicators and the results of abdominal ultrasound. The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines for the diagnosis and treatment of nonalcoholic fatty liver disease in 2008. Results In total, 95,924 subjects were analyzed in this study. The prevalence rate of lean-NAFLD was 8.16%, among which 7.58% had mild steatosis, and 0.58% had moderate and severe steatosis. The prevalence of fatty liver was increased progressively with SUA. Among which the prevalence of mild fatty liver from Q1 to Q4 were 10.33%, 18.39%, 23.11% and 25.93%; the prevalence of moderate and severe fatty liver from Q1 to Q4 were 1.06%, 2.82%, 5.05% and 7.27%. Lean-subjects with hyperuricemia had an OR of 1.718 (95% CI 1.622–1.820) to have NAFLD, after adjusted for other metabolic disorders. The area under curve (AUC) for detecting mild fatty liver based on SUA was 0.70; and the AUC for detecting moderate and severe fatty liver based on SUA was 0.78. Conclusions Our data showed positive associations between elevated SUA levels and lean-NAFLD risk in the inland Chinese adults, independent of other metabolic factors. Our study also suggests that SUA could be considered as a simple and non-invasive method to follow up patients with lean-NAFLD.http://link.springer.com/article/10.1186/s12944-017-0531-5Nonalcoholic fatty liver diseaseChineseUric acidNon-obesityUltrasonography |
| spellingShingle | Xiaoya Zheng Lilin Gong Rong Luo Hua Chen Bin Peng Wei Ren Yonghong Wang Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults Lipids in Health and Disease Nonalcoholic fatty liver disease Chinese Uric acid Non-obesity Ultrasonography |
| title | Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults |
| title_full | Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults |
| title_fullStr | Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults |
| title_full_unstemmed | Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults |
| title_short | Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults |
| title_sort | serum uric acid and non alcoholic fatty liver disease in non obesity chinese adults |
| topic | Nonalcoholic fatty liver disease Chinese Uric acid Non-obesity Ultrasonography |
| url | http://link.springer.com/article/10.1186/s12944-017-0531-5 |
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