Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates
<i>Staphylococcus aureus</i> are commensal bacteria that are found in food, water, and a variety of settings in addition to being present on the skin and mucosae of both humans and animals. They are regarded as a significant pathogen as well, with a high morbidity that can cause a variet...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/12/1654 |
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| author | Francesca Zaghen Valerio Massimo Sora Gabriele Meroni Giulia Laterza Piera Anna Martino Alessio Soggiu Luigi Bonizzi Alfonso Zecconi |
| author_facet | Francesca Zaghen Valerio Massimo Sora Gabriele Meroni Giulia Laterza Piera Anna Martino Alessio Soggiu Luigi Bonizzi Alfonso Zecconi |
| author_sort | Francesca Zaghen |
| collection | DOAJ |
| description | <i>Staphylococcus aureus</i> are commensal bacteria that are found in food, water, and a variety of settings in addition to being present on the skin and mucosae of both humans and animals. They are regarded as a significant pathogen as well, with a high morbidity that can cause a variety of illnesses. The Centers for Disease Control and Prevention (CDC) has listed them among the most virulent and resistant to antibiotics bacterial pathogens, along with <i>Escherichia coli</i>, <i>Staphylococcus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, <i>Enterococcus faecalis</i>, and <i>Enterococcus faecium</i>. Additionally, <i>S. aureus</i> is a part of the global threat posed by the existence of antimicrobial resistance (AMR). Using 26,430 <i>S. aureus</i> isolates from a global public database (NPDIB; NCBI Pathogen Detection Isolate Browser), epidemiological research was conducted. The results corroborate the evidence of notable variations in isolate distribution and ARG (Antimicrobial Resistance Gene) clusters between isolate sources and geographic origins. Furthermore, a link between the isolates from human and animal populations is suggested by the ARG cluster patterns. This result and the widespread dissemination of the pathogens among animal and human populations highlight how crucial it is to learn more about the epidemiology of these antibiotic-resistance-related infections using a One Health approach. |
| first_indexed | 2024-03-08T21:04:04Z |
| format | Article |
| id | doaj.art-ea68f6b87a3a4fa39a21f8f3b097c1b6 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-08T21:04:04Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ea68f6b87a3a4fa39a21f8f3b097c1b62023-12-22T13:47:46ZengMDPI AGAntibiotics2079-63822023-11-011212165410.3390/antibiotics12121654Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of IsolatesFrancesca Zaghen0Valerio Massimo Sora1Gabriele Meroni2Giulia Laterza3Piera Anna Martino4Alessio Soggiu5Luigi Bonizzi6Alfonso Zecconi7Department of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, Italy<i>Staphylococcus aureus</i> are commensal bacteria that are found in food, water, and a variety of settings in addition to being present on the skin and mucosae of both humans and animals. They are regarded as a significant pathogen as well, with a high morbidity that can cause a variety of illnesses. The Centers for Disease Control and Prevention (CDC) has listed them among the most virulent and resistant to antibiotics bacterial pathogens, along with <i>Escherichia coli</i>, <i>Staphylococcus</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i>, <i>Enterococcus faecalis</i>, and <i>Enterococcus faecium</i>. Additionally, <i>S. aureus</i> is a part of the global threat posed by the existence of antimicrobial resistance (AMR). Using 26,430 <i>S. aureus</i> isolates from a global public database (NPDIB; NCBI Pathogen Detection Isolate Browser), epidemiological research was conducted. The results corroborate the evidence of notable variations in isolate distribution and ARG (Antimicrobial Resistance Gene) clusters between isolate sources and geographic origins. Furthermore, a link between the isolates from human and animal populations is suggested by the ARG cluster patterns. This result and the widespread dissemination of the pathogens among animal and human populations highlight how crucial it is to learn more about the epidemiology of these antibiotic-resistance-related infections using a One Health approach.https://www.mdpi.com/2079-6382/12/12/1654<i>S. aureus</i>One Healthantimicrobial resistancemolecular epidemiologygeographical distribution |
| spellingShingle | Francesca Zaghen Valerio Massimo Sora Gabriele Meroni Giulia Laterza Piera Anna Martino Alessio Soggiu Luigi Bonizzi Alfonso Zecconi Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates Antibiotics <i>S. aureus</i> One Health antimicrobial resistance molecular epidemiology geographical distribution |
| title | Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates |
| title_full | Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates |
| title_fullStr | Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates |
| title_full_unstemmed | Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates |
| title_short | Epidemiology of Antimicrobial Resistance Genes in <i>Staphylococcus aureus</i> Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates |
| title_sort | epidemiology of antimicrobial resistance genes in i staphylococcus aureus i isolates from a public database from a one health perspective sample origin and geographical distribution of isolates |
| topic | <i>S. aureus</i> One Health antimicrobial resistance molecular epidemiology geographical distribution |
| url | https://www.mdpi.com/2079-6382/12/12/1654 |
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