2′-Hydroxycinnamaldehyde mitigates acetaminophen-induced acute liver injury by inhibiting the Warburg effect-mediated pyroptosis via the PKM2-NLRP3 axis

2′-Hydroxycinnamaldehyde mitigates acetaminophen-induced acute liver injury by inhibiting the Warburg effect-mediated pyroptosis via the PKM2-NLRP3 axis

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver injury. However, the underlying mechanisms appear to be multifaceted and there are few effective treatments. In this study, we used the 2′-Hydroxycinnamaldehyde (HCA), an active ingredient extracted from cinnamon stem bar...

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Detalhes bibliográficos
Principais autores: Luying Zhao, Jun Xu, Xiangting Zhang, Qian Xu, Kanglei Ying, Weimin Cai, Yinrong Ding, Huiya Ying, Xian Song, Zhuoyan Chen, Liuwei Zeng, Xiao Wu, Ruoru Zhou, Yuan Zeng, Fujun Yu
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2023-11-01
coleção:Journal of Functional Foods
Assuntos:
Acute liver injury
Pyroptosis
Aerobic glycolysis
2′-Hydroxycinnamaldehyde
Pyruvate kinase M2
NLRP3 inflammasome
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1756464623004723

Internet

http://www.sciencedirect.com/science/article/pii/S1756464623004723

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