Detection of Extended-Spectrum ß-Lactamases in Gram Negative Bacilli Isolated from Intensive–Care Units
Resistance to broad spectrum ß-lactam antibiotics due to extended-spectrum ß-lactamases (ESBL) has emerged in clinical gram negative isolates, but with considerable variation between hospitals. In this study; ESBL in clinical gram negative isolates were detected by investigating the synergistic effe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bilimsel Tip Yayinevi
1997-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1997-2-2-105-108.pdf |
| Summary: | Resistance to broad spectrum ß-lactam antibiotics due to extended-spectrum ß-lactamases (ESBL) has emerged in clinical gram negative isolates, but with considerable variation between hospitals. In this study; ESBL in clinical gram negative isolates were detected by investigating the synergistic effect of the combination of clavulanic acid+amoxicillin (AMC) with cefotaxime (CTX), ceftazidime (CAZ) and aztreonam (ATM) in double disk synergy test. 105 clinical isolates from the patients in intensive-care units were comprising 50 Kebsiella spp, 14 Enterobacter spp, 19 E. coli, 11 P. aeruginosa, 9 nonfermentative gram negative bacilli (NGNB) and 2 Citrobacter spp. Synergistic effect with CTX, CAZ and ATM was detected in 34% of Klebsiella spp (17/50), 57.8% of E. Coli (11/19), 18.2% of P. aeruginosa (2/11), 14.2% of Enterobacter spp (2/14) and 11.1% of NGNB (1/9). |
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| ISSN: | 1300-932X 1300-932X |