The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study
Athletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/6/969 |
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| author | Massimo Pasqualetti Maria Elisabetta Onori Giulia Canu Giacomo Moretti Angelo Minucci Silvia Baroni Alvaro Mordente Andrea Urbani Christel Galvani |
| author_facet | Massimo Pasqualetti Maria Elisabetta Onori Giulia Canu Giacomo Moretti Angelo Minucci Silvia Baroni Alvaro Mordente Andrea Urbani Christel Galvani |
| author_sort | Massimo Pasqualetti |
| collection | DOAJ |
| description | Athletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modulation of genetic influence on rugby-specific physical performance. Twenty-seven elite rugby union players were involved in the study during the in-season phase. Molecular genotyping was performed for: angiotensin-converting enzyme (<i>ACE</i> rs4646994), alfa-actinin-3 (<i>ACTN3</i> rs1815739) and monocarboxylate transporter 1 (<i>MCT1</i> rs1049434) and their variants. Lean mass index (from skinfolds), lower-limb explosive power (countermovement jump), agility (505), speed (20 m), maximal aerobic power (Yo-yo intermittent recovery test level 1) and repeated sprint ability (12 × 20 m) were evaluated. In our rugby union players <i>ACE</i> and <i>ACTN3</i> variants did not show any influence on athletic performance. <i>MCT1</i> analysis showed that TT-variant players had the highest peak vertical power (<i>p</i> = 0.037) while the ones with the AA genotype were the fastest in both agility and sprint tests (<i>p</i> = 0.006 and <i>p</i> = 0.012, respectively). Considering the T-dominant model, the AA genotype remains the fastest in both tests (agility: <i>p</i> = 0.013, speed: <i>p</i> = 0.017). Only the <i>MCT1</i> rs1049434 A allele seems to be advantageous for elite rugby union players, particularly when power and speed are required. |
| first_indexed | 2024-03-09T23:44:17Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T23:44:17Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ea701d963bf84e2da8be585738b4fe412023-11-23T16:47:05ZengMDPI AGGenes2073-44252022-05-0113696910.3390/genes13060969The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary StudyMassimo Pasqualetti0Maria Elisabetta Onori1Giulia Canu2Giacomo Moretti3Angelo Minucci4Silvia Baroni5Alvaro Mordente6Andrea Urbani7Christel Galvani8UOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyUOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyUOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyUOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyUOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyUOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, ItalyUOC di Chimica Biochimica e Biologia Molecolare Clinica, Fondazione Policlinico Universitario A. Gemelli I.R.C.C.S., Via della Pineta Sacchetti 217, 00168 Rome, ItalyLaboratorio di Scienze Dell’esercizio Fisico e Dello Sport, Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Viale Suzzani 279, 20162 Milan, ItalyAthletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modulation of genetic influence on rugby-specific physical performance. Twenty-seven elite rugby union players were involved in the study during the in-season phase. Molecular genotyping was performed for: angiotensin-converting enzyme (<i>ACE</i> rs4646994), alfa-actinin-3 (<i>ACTN3</i> rs1815739) and monocarboxylate transporter 1 (<i>MCT1</i> rs1049434) and their variants. Lean mass index (from skinfolds), lower-limb explosive power (countermovement jump), agility (505), speed (20 m), maximal aerobic power (Yo-yo intermittent recovery test level 1) and repeated sprint ability (12 × 20 m) were evaluated. In our rugby union players <i>ACE</i> and <i>ACTN3</i> variants did not show any influence on athletic performance. <i>MCT1</i> analysis showed that TT-variant players had the highest peak vertical power (<i>p</i> = 0.037) while the ones with the AA genotype were the fastest in both agility and sprint tests (<i>p</i> = 0.006 and <i>p</i> = 0.012, respectively). Considering the T-dominant model, the AA genotype remains the fastest in both tests (agility: <i>p</i> = 0.013, speed: <i>p</i> = 0.017). Only the <i>MCT1</i> rs1049434 A allele seems to be advantageous for elite rugby union players, particularly when power and speed are required.https://www.mdpi.com/2073-4425/13/6/969rugby uniongenomics<i>ACE</i><i>ACTN3</i><i>MCT1</i>athletic performance |
| spellingShingle | Massimo Pasqualetti Maria Elisabetta Onori Giulia Canu Giacomo Moretti Angelo Minucci Silvia Baroni Alvaro Mordente Andrea Urbani Christel Galvani The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study Genes rugby union genomics <i>ACE</i> <i>ACTN3</i> <i>MCT1</i> athletic performance |
| title | The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study |
| title_full | The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study |
| title_fullStr | The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study |
| title_full_unstemmed | The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study |
| title_short | The Relationship between <i>ACE</i>, <i>ACTN3</i> and <i>MCT1</i> Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study |
| title_sort | relationship between i ace i i actn3 i and i mct1 i genetic polymorphisms and athletic performance in elite rugby union players a preliminary study |
| topic | rugby union genomics <i>ACE</i> <i>ACTN3</i> <i>MCT1</i> athletic performance |
| url | https://www.mdpi.com/2073-4425/13/6/969 |
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