Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study
IntroductionNumerous studies have suggested an association between gut microbiota and polycystic ovarian syndrome (PCOS). However, the causal relationship between these two factors remains unclear.MethodsA review of observational studies was conducted to compare changes in gut microbiota between PCO...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1280983/full |
| _version_ | 1827367390538629120 |
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| author | Junwei Sun Junwei Sun Mingyu Wang Zhisheng Kan |
| author_facet | Junwei Sun Junwei Sun Mingyu Wang Zhisheng Kan |
| author_sort | Junwei Sun |
| collection | DOAJ |
| description | IntroductionNumerous studies have suggested an association between gut microbiota and polycystic ovarian syndrome (PCOS). However, the causal relationship between these two factors remains unclear.MethodsA review of observational studies was conducted to compare changes in gut microbiota between PCOS patients and controls. The analysis focused on four levels of classification, namely, phylum, family, genus, and species/genus subgroups. To further investigate the causal relationship, Mendelian randomization (MR) was employed using genome-wide association study (GWAS) data on gut microbiota from the MiBioGen consortium, as well as GWAS data from a large meta-analysis of PCOS. Additionally, a reverse MR was performed, and the results were verified through sensitivity analyses.ResultsThe present review included 18 observational studies that met the inclusion and exclusion criteria. The abundance of 64 gut microbiota taxa significantly differed between PCOS patients and controls. Using the MR method, eight bacteria were identified as causally associated with PCOS. The protective effects of the genus Sellimonas on PCOS remained significant after applying Bonferroni correction. No significant heterogeneity or horizontal pleiotropy was found in the instrumental variables (IVs). Reverse MR analyses did not reveal a significant causal effect of PCOS on gut microbiota.ConclusionThe differences in gut microbiota between PCOS patients and controls vary across observational studies. However, MR analyses identified specific gut microbiota taxa that are causally related to PCOS. Future studies should investigate the gut microbiota that showed significant results in the MR analyses, as well as the underlying mechanisms of this causal relationship and its potential clinical significance. |
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| format | Article |
| id | doaj.art-ea73645a1daf4629bd9be8a93ac11c3e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T09:06:55Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-ea73645a1daf4629bd9be8a93ac11c3e2024-02-01T04:41:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.12809831280983Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization studyJunwei Sun0Junwei Sun1Mingyu Wang2Zhisheng Kan3Department of Neurosurgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Neurosurgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, ChinaDepartment of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Neurosurgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaIntroductionNumerous studies have suggested an association between gut microbiota and polycystic ovarian syndrome (PCOS). However, the causal relationship between these two factors remains unclear.MethodsA review of observational studies was conducted to compare changes in gut microbiota between PCOS patients and controls. The analysis focused on four levels of classification, namely, phylum, family, genus, and species/genus subgroups. To further investigate the causal relationship, Mendelian randomization (MR) was employed using genome-wide association study (GWAS) data on gut microbiota from the MiBioGen consortium, as well as GWAS data from a large meta-analysis of PCOS. Additionally, a reverse MR was performed, and the results were verified through sensitivity analyses.ResultsThe present review included 18 observational studies that met the inclusion and exclusion criteria. The abundance of 64 gut microbiota taxa significantly differed between PCOS patients and controls. Using the MR method, eight bacteria were identified as causally associated with PCOS. The protective effects of the genus Sellimonas on PCOS remained significant after applying Bonferroni correction. No significant heterogeneity or horizontal pleiotropy was found in the instrumental variables (IVs). Reverse MR analyses did not reveal a significant causal effect of PCOS on gut microbiota.ConclusionThe differences in gut microbiota between PCOS patients and controls vary across observational studies. However, MR analyses identified specific gut microbiota taxa that are causally related to PCOS. Future studies should investigate the gut microbiota that showed significant results in the MR analyses, as well as the underlying mechanisms of this causal relationship and its potential clinical significance.https://www.frontiersin.org/articles/10.3389/fendo.2024.1280983/fullgut microbiotapolycystic ovarian syndromereviewMendelian randomizationcausation |
| spellingShingle | Junwei Sun Junwei Sun Mingyu Wang Zhisheng Kan Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study Frontiers in Endocrinology gut microbiota polycystic ovarian syndrome review Mendelian randomization causation |
| title | Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study |
| title_full | Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study |
| title_fullStr | Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study |
| title_full_unstemmed | Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study |
| title_short | Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study |
| title_sort | causal relationship between gut microbiota and polycystic ovary syndrome a literature review and mendelian randomization study |
| topic | gut microbiota polycystic ovarian syndrome review Mendelian randomization causation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1280983/full |
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