Association between interleukin-22 genetic polymorphisms and bladder cancer risk
OBJECTIVE:The cytokine interleukin-22 (IL-22), which is produced by T cells and natural killer cells, is associated with tumorigenesis and tumor progression in cancers. However, the role of IL-22 in bladder cancer has not been investigated.MATERIALS AND METHODS:A prospective hospital-based case-cont...
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| Format: | Article |
| Language: | English |
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Elsevier España
2015-10-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015001000686&lng=en&tlng=en |
| _version_ | 1811229068415205376 |
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| author | Tao Zhao XiaoHou Wu JiaJi Liu |
| author_facet | Tao Zhao XiaoHou Wu JiaJi Liu |
| author_sort | Tao Zhao |
| collection | DOAJ |
| description | OBJECTIVE:The cytokine interleukin-22 (IL-22), which is produced by T cells and natural killer cells, is associated with tumorigenesis and tumor progression in cancers. However, the role of IL-22 in bladder cancer has not been investigated.MATERIALS AND METHODS:A prospective hospital-based case-control study comprising 210 patients with pathologically proven bladder cancer and 210 age- and gender-matched healthy controls was conducted. The genotypes of 3 common polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) of the IL-22 gene were determined with fluorogenic 5' exonuclease assays.RESULTS:Patients with bladder cancer had a significantly higher frequency of the IL-22 -429 TT genotype [odds ratio (OR)=2.04, 95% confidence interval (CI)=1.19, 3.49; p=0.009] and -429 T allele (OR=1.42, 95% CI=1.08, 1.87; p=0.01) than the healthy controls. These findings were still significant after a Bonferroni correction. When stratifying according to the stage of bladder cancer, we found that patients with superficial bladder cancer had a significantly lower frequency of the IL-22 -429 TT genotype (OR=0.48, 95% CI=0.23, 0.98; p=0.04). When stratifying according to the grade and histological type of bladder cancer, we found no statistical association. The IL-22 +1046 T/A and IL-22 +1995 A/C gene polymorphisms were not associated with the risk of bladder cancer.CONCLUSION:To the authors' knowledge, this is the first report documenting that the IL-22 -429 C/T gene polymorphism is associated with bladder cancer risk. Additional studies are required to confirm this finding. |
| first_indexed | 2024-04-12T10:08:19Z |
| format | Article |
| id | doaj.art-ea76fbe9354344b38d364dfc4d9096a4 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:08:19Z |
| publishDate | 2015-10-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-ea76fbe9354344b38d364dfc4d9096a42022-12-22T03:37:23ZengElsevier EspañaClinics1980-53222015-10-01701068669010.6061/clinics/2015(10)05S1807-59322015001000686Association between interleukin-22 genetic polymorphisms and bladder cancer riskTao ZhaoXiaoHou WuJiaJi LiuOBJECTIVE:The cytokine interleukin-22 (IL-22), which is produced by T cells and natural killer cells, is associated with tumorigenesis and tumor progression in cancers. However, the role of IL-22 in bladder cancer has not been investigated.MATERIALS AND METHODS:A prospective hospital-based case-control study comprising 210 patients with pathologically proven bladder cancer and 210 age- and gender-matched healthy controls was conducted. The genotypes of 3 common polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) of the IL-22 gene were determined with fluorogenic 5' exonuclease assays.RESULTS:Patients with bladder cancer had a significantly higher frequency of the IL-22 -429 TT genotype [odds ratio (OR)=2.04, 95% confidence interval (CI)=1.19, 3.49; p=0.009] and -429 T allele (OR=1.42, 95% CI=1.08, 1.87; p=0.01) than the healthy controls. These findings were still significant after a Bonferroni correction. When stratifying according to the stage of bladder cancer, we found that patients with superficial bladder cancer had a significantly lower frequency of the IL-22 -429 TT genotype (OR=0.48, 95% CI=0.23, 0.98; p=0.04). When stratifying according to the grade and histological type of bladder cancer, we found no statistical association. The IL-22 +1046 T/A and IL-22 +1995 A/C gene polymorphisms were not associated with the risk of bladder cancer.CONCLUSION:To the authors' knowledge, this is the first report documenting that the IL-22 -429 C/T gene polymorphism is associated with bladder cancer risk. Additional studies are required to confirm this finding.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015001000686&lng=en&tlng=enInterleukin-22Gene PolymorphismBladder CancerCase-Control Study |
| spellingShingle | Tao Zhao XiaoHou Wu JiaJi Liu Association between interleukin-22 genetic polymorphisms and bladder cancer risk Clinics Interleukin-22 Gene Polymorphism Bladder Cancer Case-Control Study |
| title | Association between interleukin-22 genetic polymorphisms and bladder cancer risk |
| title_full | Association between interleukin-22 genetic polymorphisms and bladder cancer risk |
| title_fullStr | Association between interleukin-22 genetic polymorphisms and bladder cancer risk |
| title_full_unstemmed | Association between interleukin-22 genetic polymorphisms and bladder cancer risk |
| title_short | Association between interleukin-22 genetic polymorphisms and bladder cancer risk |
| title_sort | association between interleukin 22 genetic polymorphisms and bladder cancer risk |
| topic | Interleukin-22 Gene Polymorphism Bladder Cancer Case-Control Study |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015001000686&lng=en&tlng=en |
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