Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

Aedes aegypti transmit pathogenic arboviruses while the mosquito itself tolerates the infection. We examine a piRNA-based immunity that relies on the acquisition of viral derived cDNA (vDNA) and how this pathway discriminates between self and non-self. The piRNAs derived from these vDNAs are essenti...

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Bibliographic Details
Main Authors: Michel Tassetto, Mark Kunitomi, Zachary J Whitfield, Patrick T Dolan, Irma Sánchez-Vargas, Miguel Garcia-Knight, Isabel Ribiero, Taotao Chen, Ken E Olson, Raul Andino
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
adaptive immunity
mosquito vector
tolerance to infection
self-nonself discrimination
RNA viruses
endogenous retroviruses
Online Access:https://elifesciences.org/articles/41244

Internet

https://elifesciences.org/articles/41244

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