Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling.
The purpose of the present study is to confirm the protective effect of berberine (BBR) on gastrointestinal injury caused by acute heavy alcohol exposure, an effect that has not been reported previously. Our research details how BBR protects against gastrointestinal injuries from acute alcohol expos...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4520689?pdf=render |
| _version_ | 1819277532419063808 |
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| author | Xin-Pei Wang Fan Lei Feng Du Yu-Shuang Chai Jing-Fei Jiang Yu-Gang Wang Xuan Yu Xiao-Jin Yan Dong-Ming Xing Li-Jun Du |
| author_facet | Xin-Pei Wang Fan Lei Feng Du Yu-Shuang Chai Jing-Fei Jiang Yu-Gang Wang Xuan Yu Xiao-Jin Yan Dong-Ming Xing Li-Jun Du |
| author_sort | Xin-Pei Wang |
| collection | DOAJ |
| description | The purpose of the present study is to confirm the protective effect of berberine (BBR) on gastrointestinal injury caused by acute heavy alcohol exposure, an effect that has not been reported previously. Our research details how BBR protects against gastrointestinal injuries from acute alcohol exposure using both in vivo and in vitro experiments. Acute high alcohol concentrations lead to obvious damage to the gastrointestinal mucosa, resulting in necrosis of the intestinal mucosa. Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFα and IL-1β expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions. Alcohol consumption is a popular human social behavior worldwide, and the present study reports a comprehensive mechanism by which BBR protects against gastrointestinal injuries from alcohol stress, providing people with a novel application of BBR. |
| first_indexed | 2024-12-23T23:57:37Z |
| format | Article |
| id | doaj.art-ea79a3d741904e5bba9cd3343f1bc998 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:57:37Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ea79a3d741904e5bba9cd3343f1bc9982022-12-21T17:25:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013404410.1371/journal.pone.0134044Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling.Xin-Pei WangFan LeiFeng DuYu-Shuang ChaiJing-Fei JiangYu-Gang WangXuan YuXiao-Jin YanDong-Ming XingLi-Jun DuThe purpose of the present study is to confirm the protective effect of berberine (BBR) on gastrointestinal injury caused by acute heavy alcohol exposure, an effect that has not been reported previously. Our research details how BBR protects against gastrointestinal injuries from acute alcohol exposure using both in vivo and in vitro experiments. Acute high alcohol concentrations lead to obvious damage to the gastrointestinal mucosa, resulting in necrosis of the intestinal mucosa. Oral administration of BBR was able to significantly reduce this alcohol-induced damage, inhibit increases of alcohol-induced TNFα and IL-1β expression in gastrointestinal mucosa as well as their upstream signals TLR2 and TLR4, and regulate cytokines that modulate tight junctions. Alcohol consumption is a popular human social behavior worldwide, and the present study reports a comprehensive mechanism by which BBR protects against gastrointestinal injuries from alcohol stress, providing people with a novel application of BBR.http://europepmc.org/articles/PMC4520689?pdf=render |
| spellingShingle | Xin-Pei Wang Fan Lei Feng Du Yu-Shuang Chai Jing-Fei Jiang Yu-Gang Wang Xuan Yu Xiao-Jin Yan Dong-Ming Xing Li-Jun Du Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. PLoS ONE |
| title | Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. |
| title_full | Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. |
| title_fullStr | Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. |
| title_full_unstemmed | Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. |
| title_short | Protection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling. |
| title_sort | protection of gastrointestinal mucosa from acute heavy alcohol consumption the effect of berberine and its correlation with tlr2 4 il1β tnfα signaling |
| url | http://europepmc.org/articles/PMC4520689?pdf=render |
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