Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery
Background: Early detection of acute kidney injury (AKI) is crucial for timely intervention and improved patient outcomes after cardiac surgery. This study aimed to evaluate the potential of urinary collectrin as a novel biomarker for AKI in this patient population. Methods: In this prospective, obs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/12/3244 |
| _version_ | 1797381934891925504 |
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| author | Johanna Tichy Sahra Pajenda Martin H. Bernardi Ludwig Wagner Sylvia Ryz Monika Aiad Daniela Gerges Alice Schmidt Andrea Lassnigg Harald Herkner Wolfgang Winnicki |
| author_facet | Johanna Tichy Sahra Pajenda Martin H. Bernardi Ludwig Wagner Sylvia Ryz Monika Aiad Daniela Gerges Alice Schmidt Andrea Lassnigg Harald Herkner Wolfgang Winnicki |
| author_sort | Johanna Tichy |
| collection | DOAJ |
| description | Background: Early detection of acute kidney injury (AKI) is crucial for timely intervention and improved patient outcomes after cardiac surgery. This study aimed to evaluate the potential of urinary collectrin as a novel biomarker for AKI in this patient population. Methods: In this prospective, observational cohort study, 63 patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB) were studied at the Medical University of Vienna between 2016 and 2018. We collected urine samples prospectively at four perioperative time points, and urinary collectrin was measured using an enzyme-linked immunosorbent assay. Patients were divided into two groups, AKI and non-AKI, defined by Kidney Disease: Improving Global Outcomes Guidelines, and differences between groups were analyzed. Results: Postoperative AKI was found in 19 (30%) patients. Urine sample analysis revealed an inverse correlation between urinary collectrin and creatinine and AKI stages, as well as significant changes in collectrin levels during the perioperative course. Baseline collectrin levels were 5050 ± 3294 pg/mL, decreased after the start of CPB, reached their nadir at the end of surgery, and began to recover slightly on postoperative day (POD) 1. The most effective timepoint for distinguishing between AKI and non-AKI patients based on collectrin levels was POD 1, with collectrin levels of 2190 ± 3728 pg/mL in AKI patients and 3768 ± 3435 pg/mL in non-AKI patients (<i>p</i> = 0.01). Conclusions: Urinary collectrin shows promise as a novel biomarker for the early detection of AKI in patients undergoing cardiac surgery on CPB. Its dynamic changes throughout the perioperative period, especially on POD 1, provide valuable insights for timely diagnosis and intervention. Further research and validation studies are needed to confirm its clinical usefulness and potential impact on patient outcomes. |
| first_indexed | 2024-03-08T20:59:10Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-08T20:59:10Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ea7ab44b69e6440987a61619f259fdad2023-12-22T13:55:04ZengMDPI AGBiomedicines2227-90592023-12-011112324410.3390/biomedicines11123244Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac SurgeryJohanna Tichy0Sahra Pajenda1Martin H. Bernardi2Ludwig Wagner3Sylvia Ryz4Monika Aiad5Daniela Gerges6Alice Schmidt7Andrea Lassnigg8Harald Herkner9Wolfgang Winnicki10Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Anesthesiology, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Anesthesiology, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Anesthesiology, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, 1090 Vienna, AustriaBackground: Early detection of acute kidney injury (AKI) is crucial for timely intervention and improved patient outcomes after cardiac surgery. This study aimed to evaluate the potential of urinary collectrin as a novel biomarker for AKI in this patient population. Methods: In this prospective, observational cohort study, 63 patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB) were studied at the Medical University of Vienna between 2016 and 2018. We collected urine samples prospectively at four perioperative time points, and urinary collectrin was measured using an enzyme-linked immunosorbent assay. Patients were divided into two groups, AKI and non-AKI, defined by Kidney Disease: Improving Global Outcomes Guidelines, and differences between groups were analyzed. Results: Postoperative AKI was found in 19 (30%) patients. Urine sample analysis revealed an inverse correlation between urinary collectrin and creatinine and AKI stages, as well as significant changes in collectrin levels during the perioperative course. Baseline collectrin levels were 5050 ± 3294 pg/mL, decreased after the start of CPB, reached their nadir at the end of surgery, and began to recover slightly on postoperative day (POD) 1. The most effective timepoint for distinguishing between AKI and non-AKI patients based on collectrin levels was POD 1, with collectrin levels of 2190 ± 3728 pg/mL in AKI patients and 3768 ± 3435 pg/mL in non-AKI patients (<i>p</i> = 0.01). Conclusions: Urinary collectrin shows promise as a novel biomarker for the early detection of AKI in patients undergoing cardiac surgery on CPB. Its dynamic changes throughout the perioperative period, especially on POD 1, provide valuable insights for timely diagnosis and intervention. Further research and validation studies are needed to confirm its clinical usefulness and potential impact on patient outcomes.https://www.mdpi.com/2227-9059/11/12/3244acute kidney injurybiomarkercardiac surgerycollectrin |
| spellingShingle | Johanna Tichy Sahra Pajenda Martin H. Bernardi Ludwig Wagner Sylvia Ryz Monika Aiad Daniela Gerges Alice Schmidt Andrea Lassnigg Harald Herkner Wolfgang Winnicki Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery Biomedicines acute kidney injury biomarker cardiac surgery collectrin |
| title | Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery |
| title_full | Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery |
| title_fullStr | Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery |
| title_full_unstemmed | Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery |
| title_short | Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery |
| title_sort | urinary collectrin as promising biomarker for acute kidney injury in patients undergoing cardiac surgery |
| topic | acute kidney injury biomarker cardiac surgery collectrin |
| url | https://www.mdpi.com/2227-9059/11/12/3244 |
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