Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry
Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in La...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-03-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906718301933 |
| _version_ | 1828531023125676032 |
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| author | J. Antonio González-Hermosillo Manuel A. Baños-González Milton E. Guevara-Valdivia Jorge A. Vázquez-Acosta Manuel Odín de los Ríos Ibarra Kulio A. Aguilar-Linares Carlos Cantú-Brito José L. Leiva-Pons Gerardo Pozas-Garza Eddie A. Favela-Pérez Manlio F. Márquez María Sangeado Santos César González Aguilar Jorge Gómez Flores Karim Yarek Juárez Escobar Samantha Rodríguez Bastidas José Raúl de los Ríos Ibarra Carmen Summerson Lama José Paz Marcelo Jiménez Cruz Enrique Martínez Flores Norberto Matadamas Hernández Vanesa Esperanza Matadamas Carmona Candelaria Mancilla Rocío Camacho Casillas José Refugio Ramírez González Reynaldo Magaña Magaña Jorge Carrillo Calvillo Ulises Rojel Martínez Marco Antonio Alcocer Gamba Héctor Francisco Fernández Saldaña Laura Reséndiz Barrón Susano Lara Vaca Edgar Alfredo Rodríguez Salazar Humberto Rodríguez Reyes Marco Aurelio Islava Gálvez José Salvador Lainez Zelaya Lidia Evangelina Betancourt Hernández Yoloxochitl García Jiménez Sadoc Marín Rendon Nicolás Reyes Reyes Luis Gerardo Molina Fernández de Lara Carlos Gutiérrez González Fernando Flores Silva Alberto Zenón Baños Velasco Miguel Ernesto Beltrán Gámez Amanda Castelán Ojeda César Iván Vázquez Serna Miguel Ángel Negrete Rivera Alejandro Lechuga Martín del Campo Demetrio Kosturakis García Ramón Miguel Esturau Santaló José Luis Novelo Del Valle Luis Delgado Leal Luis Ángel Trujillo Muñoz José Fabián Hernández Díaz Mariano Miguel Guerra Raúl Isaac Márquez María Isabel Sánchez Ramírez Marcos Robledo José Manuel Enciso Muñoz Juan Carlos Núñez Fragoso Saúl Flores |
| author_facet | J. Antonio González-Hermosillo Manuel A. Baños-González Milton E. Guevara-Valdivia Jorge A. Vázquez-Acosta Manuel Odín de los Ríos Ibarra Kulio A. Aguilar-Linares Carlos Cantú-Brito José L. Leiva-Pons Gerardo Pozas-Garza Eddie A. Favela-Pérez Manlio F. Márquez María Sangeado Santos César González Aguilar Jorge Gómez Flores Karim Yarek Juárez Escobar Samantha Rodríguez Bastidas José Raúl de los Ríos Ibarra Carmen Summerson Lama José Paz Marcelo Jiménez Cruz Enrique Martínez Flores Norberto Matadamas Hernández Vanesa Esperanza Matadamas Carmona Candelaria Mancilla Rocío Camacho Casillas José Refugio Ramírez González Reynaldo Magaña Magaña Jorge Carrillo Calvillo Ulises Rojel Martínez Marco Antonio Alcocer Gamba Héctor Francisco Fernández Saldaña Laura Reséndiz Barrón Susano Lara Vaca Edgar Alfredo Rodríguez Salazar Humberto Rodríguez Reyes Marco Aurelio Islava Gálvez José Salvador Lainez Zelaya Lidia Evangelina Betancourt Hernández Yoloxochitl García Jiménez Sadoc Marín Rendon Nicolás Reyes Reyes Luis Gerardo Molina Fernández de Lara Carlos Gutiérrez González Fernando Flores Silva Alberto Zenón Baños Velasco Miguel Ernesto Beltrán Gámez Amanda Castelán Ojeda César Iván Vázquez Serna Miguel Ángel Negrete Rivera Alejandro Lechuga Martín del Campo Demetrio Kosturakis García Ramón Miguel Esturau Santaló José Luis Novelo Del Valle Luis Delgado Leal Luis Ángel Trujillo Muñoz José Fabián Hernández Díaz Mariano Miguel Guerra Raúl Isaac Márquez María Isabel Sánchez Ramírez Marcos Robledo José Manuel Enciso Muñoz Juan Carlos Núñez Fragoso Saúl Flores |
| author_sort | J. Antonio González-Hermosillo |
| collection | DOAJ |
| description | Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Objective: To describe the gender differences in clinical characteristics, thromboembolic risk, and antithrombotic therapy of patients with nonvalvular AF recruited in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry. Methods: A total of 1423 consecutive patients, with at least one thromboembolic risk factor were enrolled in CARMEN-AF Registry during a three-year period (2014–2017). They were categorized according to Gender. Results: Overall, 48.6% were women, mean age 70 ± 12 years. Diabetes, smoking, alcoholism, non-ischemic cardiomyopathy, coronary artery disease, and obstructive sleep apnea were higher in men. Most women were found with paroxysmal AF (40.6%), and most men with permanent AF (44.0%). No gender differences were found in the use of vitamin K antagonists (VKA) (30.5% in women vs. 28.0% in men). No gender differences were found in the use of direct oral anticoagulants (DOAC) (33.8% women vs 35.4% men). Conclusions: CARMEN-AF Registry demonstrates that in Mexico, regardless of gender, a large proportion of patients remain undertreated. No gender differences were found in the use of VKA or DOAC. Keywords: Atrial fibrillation, Gender, Thromboembolic risk, Antithrombotic therapy, Stroke, Mexico |
| first_indexed | 2024-12-11T22:31:35Z |
| format | Article |
| id | doaj.art-ea7c8d06e9484ab8af6907c4b2918255 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-11T22:31:35Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-ea7c8d06e9484ab8af6907c4b29182552022-12-22T00:48:08ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672019-03-0122117122Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registryJ. Antonio González-Hermosillo0Manuel A. Baños-González1Milton E. Guevara-Valdivia2Jorge A. Vázquez-Acosta3Manuel Odín de los Ríos Ibarra4Kulio A. Aguilar-Linares5Carlos Cantú-Brito6José L. Leiva-Pons7Gerardo Pozas-Garza8Eddie A. Favela-Pérez9Manlio F. Márquez10María Sangeado Santos11César González Aguilar12Jorge Gómez Flores13Karim Yarek Juárez Escobar14Samantha Rodríguez Bastidas15José Raúl de los Ríos Ibarra16Carmen Summerson Lama17José Paz Marcelo Jiménez Cruz18Enrique Martínez Flores19Norberto Matadamas Hernández20Vanesa Esperanza Matadamas Carmona21Candelaria Mancilla22Rocío Camacho Casillas23José Refugio Ramírez González24Reynaldo Magaña Magaña25Jorge Carrillo Calvillo26Ulises Rojel Martínez27Marco Antonio Alcocer Gamba28Héctor Francisco Fernández Saldaña29Laura Reséndiz Barrón30Susano Lara Vaca31Edgar Alfredo Rodríguez Salazar32Humberto Rodríguez Reyes33Marco Aurelio Islava Gálvez34José Salvador Lainez Zelaya35Lidia Evangelina Betancourt Hernández36Yoloxochitl García Jiménez37Sadoc Marín Rendon38Nicolás Reyes Reyes39Luis Gerardo Molina Fernández de Lara40Carlos Gutiérrez González41Fernando Flores Silva42Alberto Zenón Baños Velasco43Miguel Ernesto Beltrán Gámez44Amanda Castelán Ojeda45César Iván Vázquez Serna46Miguel Ángel Negrete Rivera47Alejandro Lechuga Martín del Campo48Demetrio Kosturakis García49Ramón Miguel Esturau Santaló50José Luis Novelo Del Valle51Luis Delgado Leal52Luis Ángel Trujillo Muñoz53José Fabián Hernández Díaz54Mariano Miguel Guerra55Raúl Isaac Márquez56María Isabel Sánchez Ramírez57Marcos Robledo58José Manuel Enciso Muñoz59Juan Carlos Núñez Fragoso60Saúl Flores61Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Belisario Domínguez XVI, Tlalpan, Mexico City P. C. 14080, MexicoCentro de Investigación y Posgrado, División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco (UJAT), Avenida Gregorio Méndez Magaña 2836 A, Tamulte, Villahermosa, Tabasco P. C. 86150, MexicoUnidad Médica de Alta Especialidad del Hospital de Especialidades “Dr. Antonio Fraga Mouret”, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Seris esquina Zaachila, La Raza, Azcapotzalco, Mexico City P. C. 02990, MexicoHospital Regional de PEMEX Ciudad Madero, 20 de noviembre, Jardín, Madero P. C. 89440, Tamaulipas, MexicoSINACOR, Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada S.C., Río Choix 922, Antonio Rosales, Culiacán, Sinaloa P. C. 80230, MexicoHospital Regional No. 1 Tijuana, Instituto Mexicano del Seguro Social, Canadá 16801, Río Tijuana Tercera Etapa, Tijuana, Baja California P. C. 22226, MexicoDepartament of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga 15, Belisario Domínguez, Tlalpan, Mexico City P. C. 14080, MexicoHospital Central “Dr. Ignacio Morones Prieto”, Av. Venustiano Carranza 2395, Zona Universitaria, San Luis Potosí, San Luis Potosí P. C. 78216, MexicoInstituto de Cardiología y Medicina Vascular Hospital Zambrano, Tec Salud, Batallón San Patricio 112, Real de San Agustín, San Pedro Garza García, Nuevo León P. C. 66278, MexicoStar Medica Mérida, Calle 26 199, Altabrisa, Mérida, Yucatán P. C. 97133, MexicoInstituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Belisario Domínguez XVI, Tlalpan, Mexico City P. C. 14080, Mexico; Corresponding author at: Department of Electrocardiology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Belisario Domínguez XVI, Tlalpan, Mexico City, Mexico.Hospital Regional de Alta Especialidad “Juan Graham Casasús” SSA, Villahermosa, TabascoHospital Regional de Alta Especialidad “Juan Graham Casasús” SSA, Villahermosa, TabascoInstituto Nacional de Cardiología “Ignacio Chávez”, Ciudad de México, MexicoHospital de Especialidades del Centro Médico Nacional “La Raza” IMSS, Ciudad de México, MexicoHospital Civil de Culiacán, Sinaloa, MexicoHospital Civil de Culiacán, Sinaloa, MexicoHospital Regional No. 1 IMSS, Tijuana, Baja California, MexicoHospital de Cardiología del Centro Médico Nacional “Siglo XXI” IMSS, Ciudad de México, MexicoHospital de Cardiología del Centro Médico Nacional “Siglo XXI” IMSS, Ciudad de México, MexicoHospital General de Acapulco, Guerrero, MexicoHospital General de Acapulco, Guerrero, MexicoHospital General de Acapulco, Guerrero, MexicoUnidad Médica de Alta Especialidad No. 71 IMSS, Torreón, Coahuila, MexicoUnidad Médica de Alta Especialidad No. 71 IMSS, Torreón, Coahuila, MexicoHospital General de Uruapan, MichoacánHospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí, San Luis Potosí, MexicoHospital General del Sur de Puebla, Puebla, MexicoInstituto del Corazón Querétaro, Querétaro, MexicoInstituto del Corazón Querétaro, Querétaro, MexicoInstituto del Corazón Querétaro, Querétaro, MexicoHospital Ángeles León, Guanajuato, MexicoHospital Ángeles León, Guanajuato, MexicoSociedad Cardiovascular de Aguascalientes, Aguascalientes, MexicoInstituto Nacional de Trasplantes, Cuernavaca, Morelos, MexicoInstituto Nacional de Trasplantes, Cuernavaca, Morelos, MexicoUnidad Médica de Alta Especialidad No. 14 IMSS, Veracruz, Veracruz, MexicoUnidad Médica de Alta Especialidad No. 14 IMSS, Veracruz, Veracruz, MexicoUnidad Médica de Alta Especialidad No. 14 IMSS, Veracruz, Veracruz, MexicoHospital Ángeles de Puebla, PueblaHospital General de México, Ciudad de México, MexicoHospital General de México, Ciudad de México, MexicoInstituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Ciudad de México, MexicoHospital General de Culiacán, Sinaloa, MexicoHospital Ángeles Tijuana, Baja California, MexicoCentro Médico Nacional del Noroeste IMSS, Ciudad Obregón, Sonora, MexicoCentro Médico Nacional del Noroeste IMSS, Ciudad Obregón, Sonora, MexicoISSEMYM, Toluca, Estado de México, MexicoHospital General de Pachuca, Hidalgo, MexicoCIMA Chihuahua, Chihuahua, MexicoHospital Civil de Guadalajara, Jalisco, MexicoHospital GE “Dr. Javier Buenfil Osorio” INDESALUD, Campeche, Campeche, MexicoHospital Hidalgo, Aguascalientes, Aguascalientes, MexicoHospital General de Zona No. 10, Manzanillo, Colima, MexicoHospital Regional de Alta Especialidad de Oaxaca, Oaxaca, Oaxaca, MexicoHospital Regional de Alta Especialidad de Oaxaca, Oaxaca, Oaxaca, MexicoHospital General de Zona No. 3 IMSS, Cancún, Quintana Roo, MexicoHospital General ISSSTE, La Paz, Baja California Sur, MexicoHospital General ISSSTE, La Paz, Baja California Sur, MexicoHospital “San Agustín”, Zacatecas, Zacatecas, MexicoHospital General de Zona No. 1 IMSS, Durango, Durango, MexicoHospital General de Zona No. 1 IMSS, Durango, Durango, MexicoBackground: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Objective: To describe the gender differences in clinical characteristics, thromboembolic risk, and antithrombotic therapy of patients with nonvalvular AF recruited in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry. Methods: A total of 1423 consecutive patients, with at least one thromboembolic risk factor were enrolled in CARMEN-AF Registry during a three-year period (2014–2017). They were categorized according to Gender. Results: Overall, 48.6% were women, mean age 70 ± 12 years. Diabetes, smoking, alcoholism, non-ischemic cardiomyopathy, coronary artery disease, and obstructive sleep apnea were higher in men. Most women were found with paroxysmal AF (40.6%), and most men with permanent AF (44.0%). No gender differences were found in the use of vitamin K antagonists (VKA) (30.5% in women vs. 28.0% in men). No gender differences were found in the use of direct oral anticoagulants (DOAC) (33.8% women vs 35.4% men). Conclusions: CARMEN-AF Registry demonstrates that in Mexico, regardless of gender, a large proportion of patients remain undertreated. No gender differences were found in the use of VKA or DOAC. Keywords: Atrial fibrillation, Gender, Thromboembolic risk, Antithrombotic therapy, Stroke, Mexicohttp://www.sciencedirect.com/science/article/pii/S2352906718301933 |
| spellingShingle | J. Antonio González-Hermosillo Manuel A. Baños-González Milton E. Guevara-Valdivia Jorge A. Vázquez-Acosta Manuel Odín de los Ríos Ibarra Kulio A. Aguilar-Linares Carlos Cantú-Brito José L. Leiva-Pons Gerardo Pozas-Garza Eddie A. Favela-Pérez Manlio F. Márquez María Sangeado Santos César González Aguilar Jorge Gómez Flores Karim Yarek Juárez Escobar Samantha Rodríguez Bastidas José Raúl de los Ríos Ibarra Carmen Summerson Lama José Paz Marcelo Jiménez Cruz Enrique Martínez Flores Norberto Matadamas Hernández Vanesa Esperanza Matadamas Carmona Candelaria Mancilla Rocío Camacho Casillas José Refugio Ramírez González Reynaldo Magaña Magaña Jorge Carrillo Calvillo Ulises Rojel Martínez Marco Antonio Alcocer Gamba Héctor Francisco Fernández Saldaña Laura Reséndiz Barrón Susano Lara Vaca Edgar Alfredo Rodríguez Salazar Humberto Rodríguez Reyes Marco Aurelio Islava Gálvez José Salvador Lainez Zelaya Lidia Evangelina Betancourt Hernández Yoloxochitl García Jiménez Sadoc Marín Rendon Nicolás Reyes Reyes Luis Gerardo Molina Fernández de Lara Carlos Gutiérrez González Fernando Flores Silva Alberto Zenón Baños Velasco Miguel Ernesto Beltrán Gámez Amanda Castelán Ojeda César Iván Vázquez Serna Miguel Ángel Negrete Rivera Alejandro Lechuga Martín del Campo Demetrio Kosturakis García Ramón Miguel Esturau Santaló José Luis Novelo Del Valle Luis Delgado Leal Luis Ángel Trujillo Muñoz José Fabián Hernández Díaz Mariano Miguel Guerra Raúl Isaac Márquez María Isabel Sánchez Ramírez Marcos Robledo José Manuel Enciso Muñoz Juan Carlos Núñez Fragoso Saúl Flores Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry International Journal of Cardiology: Heart & Vasculature |
| title | Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry |
| title_full | Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry |
| title_fullStr | Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry |
| title_full_unstemmed | Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry |
| title_short | Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry |
| title_sort | gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle income country insights from the carmen af registry |
| url | http://www.sciencedirect.com/science/article/pii/S2352906718301933 |
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