Bicarbonate Effects on Antibacterial Immunity and Mucus Glycobiology in the Cystic Fibrosis Lung: A Review With Selected Experimental Observations

Bicarbonate Effects on Antibacterial Immunity and Mucus Glycobiology in the Cystic Fibrosis Lung: A Review With Selected Experimental Observations

Abstract. The primary defect in cystic fibrosis (CF) is abnormal chloride and bicarbonate transport in the CF transmembrane conductance regulator epithelial ion channel. The apical surface of the respiratory tract is lined by an airway surface liquid (ASL) layer composed of mucin comprising mainly M...

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Bibliographic Details
Main Authors:	Ruth Siew, Tzung-Lin Ou, Samira Dahesh, Kathryn Akong, Victor Nizet
Format:	Article
Language:	English
Published:	Wolters Kluwer Health 2022-09-01
Series:	Infectious Microbes & Diseases
Online Access:	http://journals.lww.com/10.1097/IM9.0000000000000101

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