The role of Sirtuin 1 and its activators in age-related lung disease
Aging is a major driving factor in lung diseases. Age-related lung disease is associated with downregulated expression of SIRT1, an NAD+-dependent deacetylase that regulates inflammation and stress resistance. SIRT1 acts by inducing the deacetylation of various substrates and regulates several mecha...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222300361X |
| _version_ | 1797837200887382016 |
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| author | Chaoqun Sun Shuyou Bai Yanmei Liang Dewei Liu Jinyu Liao Yujuan Chen Xuanna Zhao Bin Wu Dan Huang Min Chen Dong Wu |
| author_facet | Chaoqun Sun Shuyou Bai Yanmei Liang Dewei Liu Jinyu Liao Yujuan Chen Xuanna Zhao Bin Wu Dan Huang Min Chen Dong Wu |
| author_sort | Chaoqun Sun |
| collection | DOAJ |
| description | Aging is a major driving factor in lung diseases. Age-related lung disease is associated with downregulated expression of SIRT1, an NAD+-dependent deacetylase that regulates inflammation and stress resistance. SIRT1 acts by inducing the deacetylation of various substrates and regulates several mechanisms that relate to lung aging, such as genomic instability, lung stem cell exhaustion, mitochondrial dysfunction, telomere shortening, and immune senescence. Chinese herbal medicines have many biological activities, exerting anti-inflammatory, anti-oxidation, anti-tumor, and immune regulatory effects. Recent studies have confirmed that many Chinese herbs have the effect of activating SIRT1. Therefore, we reviewed the mechanism of SIRT1 in age-related lung disease and explored the potential roles of Chinese herbs as SIRT1 activators in the treatment of age-related lung disease. |
| first_indexed | 2024-04-09T15:21:28Z |
| format | Article |
| id | doaj.art-ea7e6a23d945465bbac2211b10a832c9 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T15:21:28Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-ea7e6a23d945465bbac2211b10a832c92023-04-29T14:45:51ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-06-01162114573The role of Sirtuin 1 and its activators in age-related lung diseaseChaoqun Sun0Shuyou Bai1Yanmei Liang2Dewei Liu3Jinyu Liao4Yujuan Chen5Xuanna Zhao6Bin Wu7Dan Huang8Min Chen9Dong Wu10Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa 999078, Macao Special Administrative Region of China; Correspondence to: Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, 57 South Renmin Road, Zhanjiang 524001, China.Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaAging is a major driving factor in lung diseases. Age-related lung disease is associated with downregulated expression of SIRT1, an NAD+-dependent deacetylase that regulates inflammation and stress resistance. SIRT1 acts by inducing the deacetylation of various substrates and regulates several mechanisms that relate to lung aging, such as genomic instability, lung stem cell exhaustion, mitochondrial dysfunction, telomere shortening, and immune senescence. Chinese herbal medicines have many biological activities, exerting anti-inflammatory, anti-oxidation, anti-tumor, and immune regulatory effects. Recent studies have confirmed that many Chinese herbs have the effect of activating SIRT1. Therefore, we reviewed the mechanism of SIRT1 in age-related lung disease and explored the potential roles of Chinese herbs as SIRT1 activators in the treatment of age-related lung disease.http://www.sciencedirect.com/science/article/pii/S075333222300361XAge-related Lung DiseaseAnti-agingChinese Herbal MedicineLung AgingSIRT1 |
| spellingShingle | Chaoqun Sun Shuyou Bai Yanmei Liang Dewei Liu Jinyu Liao Yujuan Chen Xuanna Zhao Bin Wu Dan Huang Min Chen Dong Wu The role of Sirtuin 1 and its activators in age-related lung disease Biomedicine & Pharmacotherapy Age-related Lung Disease Anti-aging Chinese Herbal Medicine Lung Aging SIRT1 |
| title | The role of Sirtuin 1 and its activators in age-related lung disease |
| title_full | The role of Sirtuin 1 and its activators in age-related lung disease |
| title_fullStr | The role of Sirtuin 1 and its activators in age-related lung disease |
| title_full_unstemmed | The role of Sirtuin 1 and its activators in age-related lung disease |
| title_short | The role of Sirtuin 1 and its activators in age-related lung disease |
| title_sort | role of sirtuin 1 and its activators in age related lung disease |
| topic | Age-related Lung Disease Anti-aging Chinese Herbal Medicine Lung Aging SIRT1 |
| url | http://www.sciencedirect.com/science/article/pii/S075333222300361X |
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