Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study
ObjectiveThe objective of this study was to examine the influence of repeated embryo implantation failures on pregnancy outcomes among patients under 40 years of age undergoing in vitro fertilization/intracytoplasmic sperm injection embryo transfer (IVF/ICSI-ET).Materials and methodsA retrospective...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1243402/full |
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| author | Yuan Fang Yuan Fang Fan Jingjing Fan Jingjing Cheng Tiantain Cheng Tiantain Xie Huanhuan Xie Huanhuan He Qiaohua He Qiaohua |
| author_facet | Yuan Fang Yuan Fang Fan Jingjing Fan Jingjing Cheng Tiantain Cheng Tiantain Xie Huanhuan Xie Huanhuan He Qiaohua He Qiaohua |
| author_sort | Yuan Fang |
| collection | DOAJ |
| description | ObjectiveThe objective of this study was to examine the influence of repeated embryo implantation failures on pregnancy outcomes among patients under 40 years of age undergoing in vitro fertilization/intracytoplasmic sperm injection embryo transfer (IVF/ICSI-ET).Materials and methodsA retrospective analysis was conducted on the clinical data of 13,172 patients who underwent 16,975 IVF/ICSI-ET treatment cycles at Henan Reproductive Hospital between January 1, 2015, and December 31, 2018. Patients were categorized into four groups based on the number of previous embryo implantation failure cycles: Group A=no implantation failure, Group B= 1 implantation failure, Group C=2 implantation failures, Group D=≥3 implantation failures. Baseline characteristics and pregnancy outcomes were compared among the four groups. The impact of the number of previous embryo implantation failures on pregnancy outcomes among IVF/ICSI-ET patients was investigated using univariate and multiple regression analyses.ResultsUnivariate logistic regression analysis demonstrated that factors such as the number of previous embryo implantation failures, female age, basal follicle count, endometrial thickness, total number of oocytes retrieved, type of cycle, number of high-quality embryos transferred, and stage of embryo development significantly affected implantation rate, clinical pregnancy rate, early spontaneous abortion rate, and live birth rate (all P < 0.05). The duration of infertility and anti-Mullerian hormone (AMH) levels were also found to influence implantation rate, clinical pregnancy rate, and live birth rate (all P < 0.05). Upon conducting multivariate logistic regression analysis and adjusting for confounding factors such as age, AMH levels, basal follicle count, endometrial thickness, total number of oocytes obtained, cycle type, number of high-quality embryos transferred, ovarian stimulation protocol, and stage of embryo development, it was revealed that, compared to Group A, Groups B, C, and D exhibited significantly lower implantation and live birth rates, as well as a significantly higher risk of early spontaneous abortion (all P < 0.05).ConclusionsThe number of previous embryo implantation failures is an independent factor affecting implantation rate, clinical pregnancy rate, spontaneous abortion rate and live birth rate of patients underwent IVF/ICSI-ET. With the increase of the number of previous embryo implantation failures, the implantation rate, clinical pregnancy rate and live birth rate of patients underwent IVF/ICSI-ET decreased significantly, and the rate of early spontaneous abortion gradually increased. |
| first_indexed | 2024-04-24T23:58:50Z |
| format | Article |
| id | doaj.art-ea7fac01c0e8443f925bc02622b44a80 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T23:58:50Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-ea7fac01c0e8443f925bc02622b44a802024-03-14T10:51:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12434021243402Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort studyYuan Fang0Yuan Fang1Fan Jingjing2Fan Jingjing3Cheng Tiantain4Cheng Tiantain5Xie Huanhuan6Xie Huanhuan7He Qiaohua8He Qiaohua9Reproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, ChinaPeople's Hospital of Henan University, Zhengzhou, ChinaReproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, ChinaPeople's Hospital of Henan University, Zhengzhou, ChinaReproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, ChinaPeople's Hospital of Henan University, Zhengzhou, ChinaReproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, ChinaPeople's Hospital of Henan University, Zhengzhou, ChinaReproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, ChinaPeople's Hospital of Henan University, People's Hospital of Zhengzhou University, Zhengzhou, ChinaObjectiveThe objective of this study was to examine the influence of repeated embryo implantation failures on pregnancy outcomes among patients under 40 years of age undergoing in vitro fertilization/intracytoplasmic sperm injection embryo transfer (IVF/ICSI-ET).Materials and methodsA retrospective analysis was conducted on the clinical data of 13,172 patients who underwent 16,975 IVF/ICSI-ET treatment cycles at Henan Reproductive Hospital between January 1, 2015, and December 31, 2018. Patients were categorized into four groups based on the number of previous embryo implantation failure cycles: Group A=no implantation failure, Group B= 1 implantation failure, Group C=2 implantation failures, Group D=≥3 implantation failures. Baseline characteristics and pregnancy outcomes were compared among the four groups. The impact of the number of previous embryo implantation failures on pregnancy outcomes among IVF/ICSI-ET patients was investigated using univariate and multiple regression analyses.ResultsUnivariate logistic regression analysis demonstrated that factors such as the number of previous embryo implantation failures, female age, basal follicle count, endometrial thickness, total number of oocytes retrieved, type of cycle, number of high-quality embryos transferred, and stage of embryo development significantly affected implantation rate, clinical pregnancy rate, early spontaneous abortion rate, and live birth rate (all P < 0.05). The duration of infertility and anti-Mullerian hormone (AMH) levels were also found to influence implantation rate, clinical pregnancy rate, and live birth rate (all P < 0.05). Upon conducting multivariate logistic regression analysis and adjusting for confounding factors such as age, AMH levels, basal follicle count, endometrial thickness, total number of oocytes obtained, cycle type, number of high-quality embryos transferred, ovarian stimulation protocol, and stage of embryo development, it was revealed that, compared to Group A, Groups B, C, and D exhibited significantly lower implantation and live birth rates, as well as a significantly higher risk of early spontaneous abortion (all P < 0.05).ConclusionsThe number of previous embryo implantation failures is an independent factor affecting implantation rate, clinical pregnancy rate, spontaneous abortion rate and live birth rate of patients underwent IVF/ICSI-ET. With the increase of the number of previous embryo implantation failures, the implantation rate, clinical pregnancy rate and live birth rate of patients underwent IVF/ICSI-ET decreased significantly, and the rate of early spontaneous abortion gradually increased.https://www.frontiersin.org/articles/10.3389/fendo.2023.1243402/fullIVF/ICSIimplantation rate (IR)Live birth rate (LBR)pregnancy outcomerecurrent implantation failure (RIF) |
| spellingShingle | Yuan Fang Yuan Fang Fan Jingjing Fan Jingjing Cheng Tiantain Cheng Tiantain Xie Huanhuan Xie Huanhuan He Qiaohua He Qiaohua Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study Frontiers in Endocrinology IVF/ICSI implantation rate (IR) Live birth rate (LBR) pregnancy outcome recurrent implantation failure (RIF) |
| title | Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study |
| title_full | Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study |
| title_fullStr | Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study |
| title_full_unstemmed | Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study |
| title_short | Impact of the number of previous embryo implantation failures on IVF/ICSI-ET pregnancy outcomes in patients younger than 40 years: a retrospective cohort study |
| title_sort | impact of the number of previous embryo implantation failures on ivf icsi et pregnancy outcomes in patients younger than 40 years a retrospective cohort study |
| topic | IVF/ICSI implantation rate (IR) Live birth rate (LBR) pregnancy outcome recurrent implantation failure (RIF) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1243402/full |
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