Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan
Abstract Background The difference in the clinical impact of alcohol consumption on kidney function based on sex remains to be elucidated. This study aimed to assess the association between the dose of alcohol consumption and the incidence of proteinuria and chronic kidney disease stratified by sex....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-022-00785-x |
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| author | Akio Tanaka Makoto Yamaguchi Takuji Ishimoto Takayuki Katsuno Hironobu Nobata Shiho Iwagaitsu Hirokazu Sugiyama Hiroshi Kinashi Shogo Banno Takahiro Imaizumi Masahiko Ando Yoko Kubo Yasuhiko Ito |
| author_facet | Akio Tanaka Makoto Yamaguchi Takuji Ishimoto Takayuki Katsuno Hironobu Nobata Shiho Iwagaitsu Hirokazu Sugiyama Hiroshi Kinashi Shogo Banno Takahiro Imaizumi Masahiko Ando Yoko Kubo Yasuhiko Ito |
| author_sort | Akio Tanaka |
| collection | DOAJ |
| description | Abstract Background The difference in the clinical impact of alcohol consumption on kidney function based on sex remains to be elucidated. This study aimed to assess the association between the dose of alcohol consumption and the incidence of proteinuria and chronic kidney disease stratified by sex. Methods This retrospective cohort study included 26,788 workers (19,702 men and 7086 women) with normal renal function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) at annual health examinations between January 2010 and March 2015 in Japan. The main exposure was alcohol consumption. The primary outcomes were the incidence of proteinuria (dipstick urinary protein ≥ 1) and incidence of low estimated glomerular filtration rate (eGFR; rate < 60 mL/min per 1.73 m2; decreased from the baseline eGFR by 25%). Results During a median observational period of 4 years (interquartile range: 2–6), 1993 (10.1%) men and 462 (6.5%) women developed proteinuria, whereas 667 (3.4%) men and 255 (3.6%) women developed low eGFR. After adjustment for clinically relevant factors using a Cox proportional hazards model, alcohol consumption of ≥ 46 g/day in females was significantly associated with the incidence of proteinuria (hazard ratio, 1.57; 95% confidence interval, 1.10–2.26) and low eGFR (hazard ratio, 1.62; 95% confidence interval, 1.04–2.53). However, no significant association between alcohol consumption and primary outcomes was observed in men. Conclusions In conclusion, daily higher alcohol consumption was significantly associated with a higher incidence of proteinuria and low eGFR among women. Women might be prone to high alcohol consumption with kidney dysfunction. |
| first_indexed | 2024-12-12T03:30:34Z |
| format | Article |
| id | doaj.art-ea8077ffbef04d61b6d112233ea9a26a |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-12T03:30:34Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-ea8077ffbef04d61b6d112233ea9a26a2022-12-22T00:39:55ZengBMCNutrition Journal1475-28912022-05-0121111010.1186/s12937-022-00785-xAssociation of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in JapanAkio Tanaka0Makoto Yamaguchi1Takuji Ishimoto2Takayuki Katsuno3Hironobu Nobata4Shiho Iwagaitsu5Hirokazu Sugiyama6Hiroshi Kinashi7Shogo Banno8Takahiro Imaizumi9Masahiko Ando10Yoko Kubo11Yasuhiko Ito12Department of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityDepartment of Nephrology and Rheumatology, Aichi Medical UniversityData Coordinating Center, Department of Advanced Medicine, Nagoya University HospitalData Coordinating Center, Department of Advanced Medicine, Nagoya University HospitalDepartment of Preventive Medicine, Nagoya University Graduate School of MedicineDepartment of Nephrology and Rheumatology, Aichi Medical UniversityAbstract Background The difference in the clinical impact of alcohol consumption on kidney function based on sex remains to be elucidated. This study aimed to assess the association between the dose of alcohol consumption and the incidence of proteinuria and chronic kidney disease stratified by sex. Methods This retrospective cohort study included 26,788 workers (19,702 men and 7086 women) with normal renal function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) at annual health examinations between January 2010 and March 2015 in Japan. The main exposure was alcohol consumption. The primary outcomes were the incidence of proteinuria (dipstick urinary protein ≥ 1) and incidence of low estimated glomerular filtration rate (eGFR; rate < 60 mL/min per 1.73 m2; decreased from the baseline eGFR by 25%). Results During a median observational period of 4 years (interquartile range: 2–6), 1993 (10.1%) men and 462 (6.5%) women developed proteinuria, whereas 667 (3.4%) men and 255 (3.6%) women developed low eGFR. After adjustment for clinically relevant factors using a Cox proportional hazards model, alcohol consumption of ≥ 46 g/day in females was significantly associated with the incidence of proteinuria (hazard ratio, 1.57; 95% confidence interval, 1.10–2.26) and low eGFR (hazard ratio, 1.62; 95% confidence interval, 1.04–2.53). However, no significant association between alcohol consumption and primary outcomes was observed in men. Conclusions In conclusion, daily higher alcohol consumption was significantly associated with a higher incidence of proteinuria and low eGFR among women. Women might be prone to high alcohol consumption with kidney dysfunction.https://doi.org/10.1186/s12937-022-00785-xAlcoholChronic kidney diseaseProteinuriaSex differenceRetrospective cohort study |
| spellingShingle | Akio Tanaka Makoto Yamaguchi Takuji Ishimoto Takayuki Katsuno Hironobu Nobata Shiho Iwagaitsu Hirokazu Sugiyama Hiroshi Kinashi Shogo Banno Takahiro Imaizumi Masahiko Ando Yoko Kubo Yasuhiko Ito Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan Nutrition Journal Alcohol Chronic kidney disease Proteinuria Sex difference Retrospective cohort study |
| title | Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan |
| title_full | Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan |
| title_fullStr | Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan |
| title_full_unstemmed | Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan |
| title_short | Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan |
| title_sort | association of alcohol consumption with the incidence of proteinuria and chronic kidney disease a retrospective cohort study in japan |
| topic | Alcohol Chronic kidney disease Proteinuria Sex difference Retrospective cohort study |
| url | https://doi.org/10.1186/s12937-022-00785-x |
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