Discovery of Taurocholic Acid Sodium Hydrate as a Novel Repurposing Drug for Intervertebral Disc Degeneration by Targeting MAPK3

Discovery of Taurocholic Acid Sodium Hydrate as a Novel Repurposing Drug for Intervertebral Disc Degeneration by Targeting MAPK3

Objective Nowadays, more than 90% of people over 50 years suffer from intervertebral disc degeneration (IDD), but there are exist no ideal drugs. The aim of this study is to identify a new drug for IDD. Methods An approved small molecular drug library including 2040 small molecular compounds was use...

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Bibliographic Details
Main Authors: Ping Li, Zesen Chen, Keyu Meng, Yanlin Chen, Jiajia Xu, Xin Xiang, Xiuhua Wu, Zhiping Huang, Ruijun Lai, Peng Li, Zhongming Lai, Xiang Ao, Zhongyuan Liu, Kaifan Yang, Xiaochun Bai, Zhongmin Zhang
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Orthopaedic Surgery
Subjects:
Chondrogenesis
Intervertebral Disc Degeneration (IDD)
Mesenchymal Stem Cells (MSCs)
Osteogenesis
Taurocholic Acid Sodium Salt Hydrate (NAT)
Online Access:https://doi.org/10.1111/os.13909

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