Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake

Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake

Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel. The mechanisms by which paclitaxel is transported into neurons, which are essential for preventing neuropathy, are not well understood. We studied the uptake mechanisms of paclitaxel into neurons using inhibitors for...

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Bibliographic Details
Main Authors: Ines Klein, Jörg Isensee, Martin H. J. Wiesen, Thomas Imhof, Meike K. Wassermann, Carsten Müller, Tim Hucho, Manuel Koch, Helmar C. Lehmann
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
paclitaxel
taxol
CIPN
OATP
OATP1B2
OATP1A1
Online Access:https://www.mdpi.com/2073-4409/12/9/1249

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