THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
Abstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of mono...
| Autores principales: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Russian |
| Publicado: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Colección: | Медицинская иммунология |
| Materias: | |
| Acceso en línea: | https://www.mimmun.ru/mimmun/article/view/423 |
| _version_ | 1826534293422211072 |
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| author | L. V. Sakhno M. A. Tihonova V. S. Kozhevnikov V. V. Senjukov N. V. Pronkina S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh |
| author_facet | L. V. Sakhno M. A. Tihonova V. S. Kozhevnikov V. V. Senjukov N. V. Pronkina S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh |
| author_sort | L. V. Sakhno |
| collection | DOAJ |
| description | Abstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of monocytes with intracellular TNF–α, and negative correlation between these parameters was revealed. On the contrary, the higher level of CD14+CD16+ monocytes was connected with increased number of IL–10–producing monocytes. IL–10–producing cells were established mainly in the population of CD16+ monocytes and so population of CD14+CD16+ monocytes may represent the cells with suppressive activity. Really, the CD14+CD16+ monocytes were increased in patients with defective antigen specific response. Enhancement of CD14+CD16+ monocytes was observed in patients with active tuberculosis independently of form and dissemination of disease and did not connected with concomitant viral or bacterial infection. (Med. Immunol., 2005, vol.7, № 1, pp 49556) |
| first_indexed | 2024-03-08T05:51:10Z |
| format | Article |
| id | doaj.art-ea828fc8e6cb49fca53fd26c83a15e6c |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:20:43Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-ea828fc8e6cb49fca53fd26c83a15e6c2025-03-11T17:59:03ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0171495610.15789/1563-0625-2005-1-49-56420THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSISL. V. Sakhno0M. A. Tihonova1V. S. Kozhevnikov2V. V. Senjukov3N. V. Pronkina4S. D. Nikonov5O. A. Zhdanov6A. A. Ostanin7E. R. Chernykh8НИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскНИИ клинической иммунологии СО РАМН, Городская клиническая специализированная туберкулезная больница №1, НовосибирскAbstract. Peripheral blood monocytes were investigated in the patients with pulmonary tuberculosis. It was established that population of CD14+16+ monocytes was twofold increased in the patients with tuberculosis. The higher level of CD14+CD16+ monocytes was associated with decreasing number of monocytes with intracellular TNF–α, and negative correlation between these parameters was revealed. On the contrary, the higher level of CD14+CD16+ monocytes was connected with increased number of IL–10–producing monocytes. IL–10–producing cells were established mainly in the population of CD16+ monocytes and so population of CD14+CD16+ monocytes may represent the cells with suppressive activity. Really, the CD14+CD16+ monocytes were increased in patients with defective antigen specific response. Enhancement of CD14+CD16+ monocytes was observed in patients with active tuberculosis independently of form and dissemination of disease and did not connected with concomitant viral or bacterial infection. (Med. Immunol., 2005, vol.7, № 1, pp 49556)https://www.mimmun.ru/mimmun/article/view/423cd14+cd16+monocytesintracellular cytokinesppd–anergypulmonary tuberculosis |
| spellingShingle | L. V. Sakhno M. A. Tihonova V. S. Kozhevnikov V. V. Senjukov N. V. Pronkina S. D. Nikonov O. A. Zhdanov A. A. Ostanin E. R. Chernykh THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS Медицинская иммунология cd14+cd16+monocytes intracellular cytokines ppd–anergy pulmonary tuberculosis |
| title | THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full | THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_fullStr | THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full_unstemmed | THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_short | THE PHENOTYPE AND FUNCTION OF MONOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_sort | phenotype and function of monocytes in patients with pulmonary tuberculosis |
| topic | cd14+cd16+monocytes intracellular cytokines ppd–anergy pulmonary tuberculosis |
| url | https://www.mimmun.ru/mimmun/article/view/423 |
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