A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients
AbstractPurpose The aim of this study was to further assess whether the platelet-to-lymphocyte ratio (PLR) is independently associated with all-cause mortality and cardiovascular mortality in maintenance hemodialysis (MHD) patients.Methods From January 1, 2014, to December 31, 2014, patients undergo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2258228 |
| _version_ | 1797211845572952064 |
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| author | Yanping Zhang Aihong Zhang Lin Wei Kaiming Ren Qian Wang Bing Shao Chen Zhao Zhuo Ren Jiuxu Bai Ning Cao |
| author_facet | Yanping Zhang Aihong Zhang Lin Wei Kaiming Ren Qian Wang Bing Shao Chen Zhao Zhuo Ren Jiuxu Bai Ning Cao |
| author_sort | Yanping Zhang |
| collection | DOAJ |
| description | AbstractPurpose The aim of this study was to further assess whether the platelet-to-lymphocyte ratio (PLR) is independently associated with all-cause mortality and cardiovascular mortality in maintenance hemodialysis (MHD) patients.Methods From January 1, 2014, to December 31, 2014, patients undergoing regular hemodialysis in the Blood Purification Center of the General Hospital of Northern Theatre Command were retrospectively selected. A total of 303 MHD patients were enrolled in accordance with the inclusion and exclusion criteria. For each patient, the endpoint of follow-up was either death or December 31, 2021. The primary endpoints were all-cause and cardiovascular death. A receiver operating characteristic (ROC) curve was drawn to detect the predictive ability of PLR, and the optimal critical value of PLR was determined to be 107.57. Kaplan–Meier curves and Cox proportional analysis were used to assess the prognostic value of PLR. We used the same method to evaluate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the prognosis of MHD patients.Results At the end of follow-up, 128 MHD patients had progressed to all-cause death, and 73 MHD patients had progressed to cardiovascular death. In multivariate Cox regression, both the high PLR group and the high NLR group were independently associated with all-cause mortality (HR 2.608, 95% CI 1.579–4.306, p < .001 vs. HR 1.634, 95% CI 1.023–2.610, p = .04). Only high PLR expression was associated with cardiovascular mortality (HR 3.379, 95% CI 1.646–6.936, p = .001).Conclusions High PLR levels can independently predict all-cause and cardiovascular mortality in MHD patients. |
| first_indexed | 2024-03-11T23:45:34Z |
| format | Article |
| id | doaj.art-ea82aa7588fa40ebb87c0bc5cc5df483 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T10:32:58Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-ea82aa7588fa40ebb87c0bc5cc5df4832024-04-12T14:34:28ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145210.1080/0886022X.2023.2258228A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patientsYanping Zhang0Aihong Zhang1Lin Wei2Kaiming Ren3Qian Wang4Bing Shao5Chen Zhao6Zhuo Ren7Jiuxu Bai8Ning Cao9Department of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaAbstractPurpose The aim of this study was to further assess whether the platelet-to-lymphocyte ratio (PLR) is independently associated with all-cause mortality and cardiovascular mortality in maintenance hemodialysis (MHD) patients.Methods From January 1, 2014, to December 31, 2014, patients undergoing regular hemodialysis in the Blood Purification Center of the General Hospital of Northern Theatre Command were retrospectively selected. A total of 303 MHD patients were enrolled in accordance with the inclusion and exclusion criteria. For each patient, the endpoint of follow-up was either death or December 31, 2021. The primary endpoints were all-cause and cardiovascular death. A receiver operating characteristic (ROC) curve was drawn to detect the predictive ability of PLR, and the optimal critical value of PLR was determined to be 107.57. Kaplan–Meier curves and Cox proportional analysis were used to assess the prognostic value of PLR. We used the same method to evaluate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the prognosis of MHD patients.Results At the end of follow-up, 128 MHD patients had progressed to all-cause death, and 73 MHD patients had progressed to cardiovascular death. In multivariate Cox regression, both the high PLR group and the high NLR group were independently associated with all-cause mortality (HR 2.608, 95% CI 1.579–4.306, p < .001 vs. HR 1.634, 95% CI 1.023–2.610, p = .04). Only high PLR expression was associated with cardiovascular mortality (HR 3.379, 95% CI 1.646–6.936, p = .001).Conclusions High PLR levels can independently predict all-cause and cardiovascular mortality in MHD patients.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2258228Platelet-to-lymphocyte ratiomaintenance hemodialysisall-cause mortalitycardiovascular mortalityneutrophil-to-lymphocyte ratio |
| spellingShingle | Yanping Zhang Aihong Zhang Lin Wei Kaiming Ren Qian Wang Bing Shao Chen Zhao Zhuo Ren Jiuxu Bai Ning Cao A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients Renal Failure Platelet-to-lymphocyte ratio maintenance hemodialysis all-cause mortality cardiovascular mortality neutrophil-to-lymphocyte ratio |
| title | A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients |
| title_full | A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients |
| title_fullStr | A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients |
| title_full_unstemmed | A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients |
| title_short | A high platelet-to-lymphocyte ratio predicts all-cause mortality and cardiovascular mortality in maintenance hemodialysis patients |
| title_sort | high platelet to lymphocyte ratio predicts all cause mortality and cardiovascular mortality in maintenance hemodialysis patients |
| topic | Platelet-to-lymphocyte ratio maintenance hemodialysis all-cause mortality cardiovascular mortality neutrophil-to-lymphocyte ratio |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2258228 |
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