Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3
Aim Steady progress in intensive treatment worldwide has increased the survival of immature neonates, but with multiple invasive procedures, which have increased the risk of infection, thus the bacterial resistance to antibiotics. The aim of this study was to analyse the epidemiology of multidrug re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2020-07-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | http://ljkzedo.ba/mgpdf/mg33/24_Hadzic_1157_A.pdf |
| _version_ | 1811266975895126016 |
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| author | Devleta Hadžić Fahrija Skokić Selmira Brkić Amina Saračević Delila Softić Dženana Softić |
| author_facet | Devleta Hadžić Fahrija Skokić Selmira Brkić Amina Saračević Delila Softić Dženana Softić |
| author_sort | Devleta Hadžić |
| collection | DOAJ |
| description | Aim Steady progress in intensive treatment worldwide has increased the survival of immature neonates, but with multiple invasive procedures, which have increased the risk of infection, thus the bacterial resistance to antibiotics. The aim of this study was to analyse the epidemiology of multidrug resistance pathogens as causative agents of neonatal sepsis in the neonatal intensive care unit.
Methods A retrospective cohort study conducted at the Intensive care unit of the Paediatric Clinic of Tuzla over a three-year period (2016-2018) analysed epidemiology of neonatal sepsis caused by multidrug resistance pathogens. Statistical analysis applied standard methods, and the research was approved by the Ethics Committee of the institution.
Results Of the total of 921 treated neonates, multidrug resistance (MDR) pathogens among causative agents of neonatal sepsis were found in 22 neonates (2.38%) with no gender difference. Prematurity and low birth weight were confirmed as the most significant risk factors. From the maternal risk factors a significant difference was found in the first birth and in vitro fertilization. Clinically, MDR sepsis manifested frequently as late onset sepsis, with longer hospital stay and higher mortality. The findings of leukopenia, thrombocytopenia and coagulation disorders were significant. Gram negative bacteria were frequently isolated, in particular Acinetobacter, which showed the greatest resistance to antibiotics.
Conclusion Neonatal MDR sepsis is a threat to life, it complicates the treatment, increases costs and mortality. Outcomes can be improved by preventive strategies, earlier and more accurate diagnosis and rational use of antibiotics. |
| first_indexed | 2024-04-12T20:53:03Z |
| format | Article |
| id | doaj.art-ea83a9e83c8c4b5f9ffba703a81bcab7 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-04-12T20:53:03Z |
| publishDate | 2020-07-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-ea83a9e83c8c4b5f9ffba703a81bcab72022-12-22T03:17:04ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452020-07-0117237538210.17392/1157-20Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3Devleta Hadžić0Fahrija Skokić1Selmira Brkić2Amina Saračević3Delila Softić4Dženana Softić5Paediatric Clinic, University Clinical Centre of Tuzla, Bosnia and HerzegovinaPaediatric Clinic, University Clinical Centre of Tuzla, Bosnia and HerzegovinaSchool of Medicine University of Tuzla; Bosnia and HerzegovinaPaediatric Clinic, University Clinical Centre of Tuzla, Bosnia and HerzegovinaSchool of Medicine University of Tuzla; Bosnia and HerzegovinaPaediatric Clinic, University Clinical Centre of Tuzla, Bosnia and HerzegovinaAim Steady progress in intensive treatment worldwide has increased the survival of immature neonates, but with multiple invasive procedures, which have increased the risk of infection, thus the bacterial resistance to antibiotics. The aim of this study was to analyse the epidemiology of multidrug resistance pathogens as causative agents of neonatal sepsis in the neonatal intensive care unit. Methods A retrospective cohort study conducted at the Intensive care unit of the Paediatric Clinic of Tuzla over a three-year period (2016-2018) analysed epidemiology of neonatal sepsis caused by multidrug resistance pathogens. Statistical analysis applied standard methods, and the research was approved by the Ethics Committee of the institution. Results Of the total of 921 treated neonates, multidrug resistance (MDR) pathogens among causative agents of neonatal sepsis were found in 22 neonates (2.38%) with no gender difference. Prematurity and low birth weight were confirmed as the most significant risk factors. From the maternal risk factors a significant difference was found in the first birth and in vitro fertilization. Clinically, MDR sepsis manifested frequently as late onset sepsis, with longer hospital stay and higher mortality. The findings of leukopenia, thrombocytopenia and coagulation disorders were significant. Gram negative bacteria were frequently isolated, in particular Acinetobacter, which showed the greatest resistance to antibiotics. Conclusion Neonatal MDR sepsis is a threat to life, it complicates the treatment, increases costs and mortality. Outcomes can be improved by preventive strategies, earlier and more accurate diagnosis and rational use of antibiotics.http://ljkzedo.ba/mgpdf/mg33/24_Hadzic_1157_A.pdfantibiotic resistanceincidenceintensive careneonatal early onset sepsisneonatal late onset sepsis |
| spellingShingle | Devleta Hadžić Fahrija Skokić Selmira Brkić Amina Saračević Delila Softić Dženana Softić Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 Medicinski Glasnik antibiotic resistance incidence intensive care neonatal early onset sepsis neonatal late onset sepsis |
| title | Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 |
| title_full | Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 |
| title_fullStr | Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 |
| title_full_unstemmed | Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 |
| title_short | Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 |
| title_sort | epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3 |
| topic | antibiotic resistance incidence intensive care neonatal early onset sepsis neonatal late onset sepsis |
| url | http://ljkzedo.ba/mgpdf/mg33/24_Hadzic_1157_A.pdf |
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